Department of Neonatology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, China.
Department of Pediatric Critical Illness, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, China.
Medicine (Baltimore). 2021 Oct 29;100(43):e27587. doi: 10.1097/MD.0000000000027587.
Premature infants are prone to suffer multisystem complications after birth due to the incomplete development of organ tissues and low immunity, and they require a longer period of supervised treatment in the neonatal intensive care unit (NICU). However, due to the specificity of medical care in the NICU, the sleep of preterm infants is highly susceptible that has an impact on the prognosis of preterm infants. Recently, various non-pharmacological interventions have been applied to the sleep of preterm infants in the NICU, which have shown positive outcomes. However, the efficacy and safety of them are unclear. This study aims to evaluate the effects of non-pharmacological interventions on sleep in preterm infants in the NICU through a network meta-analysis.
Randomized controlled trials of non-pharmacological interventions on sleep in preterm infants in the NICU published before September 2021 will be searched in online databases, including the Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, Wanfang, China Biomedical Literature Database, PubMed, Cochrane Library, Embase, and Web of Science. Two researchers will be independently responsible for screening and selecting eligible literatures, extracting data and evaluating the risk of bias in the included studies. Stata 14.0 software will be used for data analysis.
The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.
This study will provide comprehensive and reliable evidence-based references for the efficacy and safety in different non-pharmacological interventions on sleep in preterm infants in the NICU.
早产儿由于器官组织发育不完全和免疫力低下，出生后容易发生多系统并发症，需要在新生儿重症监护病房（NICU）接受较长时间的监护治疗。然而，由于 NICU 医疗的特殊性，早产儿的睡眠极易受到影响，这对早产儿的预后有影响。最近，各种非药物干预措施已应用于 NICU 早产儿的睡眠中，已显示出积极的结果。然而，它们的疗效和安全性尚不清楚。本研究旨在通过网络荟萃分析评估 NICU 早产儿非药物干预措施对睡眠的影响。
将在 2021 年 9 月之前在在线数据库中搜索关于 NICU 早产儿睡眠的非药物干预的随机对照试验，包括中国科学期刊数据库、中国国家知识基础设施数据库、万方、中国生物医学文献数据库、PubMed、Cochrane 图书馆、Embase 和 Web of Science。两名研究人员将独立负责筛选和选择合格文献，提取数据并评估纳入研究的偏倚风险。Stata 14.0 软件将用于数据分析。
荟萃分析的结果将提交给同行评审期刊发表。
本研究将为 NICU 早产儿不同非药物干预措施对睡眠的疗效和安全性提供全面可靠的循证参考。
