Perri-Plandé Joelle, Miremont-Salamé Ghada, Lapeyre-Mestre Maryse, Perino Justine, Gibaja Valérie, Daveluy Amélie
Centre d'Évaluation et d'Information sur la Pharmacodépendance - Addictovigilance, Service de pharmacologie médicale, CHU de Bordeaux, 33000 Bordeaux, France.
Centre d'Évaluation et d'Information sur la Pharmacodépendance - Addictovigilance, Service de pharmacologie médicale, CHU de Bordeaux, 33000 Bordeaux, France; Université de Bordeaux, Inserm, Bordeaux Population Health Research Centre, Team, Pharmacoepidemiology, UMR 1219, 33000 Bordeaux, France.
Therapie. 2025 Mar-Apr;80(2):187-195. doi: 10.1016/j.therap.2024.10.055. Epub 2024 Oct 22.
Analgesics are among the most widely used drugs worldwide. The French Addictovigilance Network (FAN) established the antalgiques stupéfiants et ordonnances sécurisées (ASOS [narcotic analgesics and secure prescriptions]) survey in order to assess the dissemination of tamper-resistant prescription forms for narcotic analgesic within the medical community, as well as the nature and evolution of the prescriptions. After outlining the missions of the FAN, this article will describe the population treated with narcotic analgesics in France, their therapeutic indications and how the data have evolved since 2007.
A cross-sectional, national, multicentre survey study was conducted that included surveys taken every year from 2007 to 2023 in a national sample of 1500 randomly selected dispensing pharmacies.
The mean age of patients, mostly women (around 60%), remained stable over the study period (63.2years in 2007, 67.6years in 2023). Most prescriptions involved morphine, oxycodone and fentanyl. Morphine and fentanyl were the reference molecules for prescribing opioid analgesics, but the sharp increase in oxycodone prescriptions between 2007 and 2015 impacted their usage. Cancer and rheumatologic pains were the main indications, with an increase in neurological indications in recent years. A focus on fentanyl and oxycodone highlights misuse patterns that are difficult to identify in other surveys.
This study demonstrates how narcotic opioids are prescribed in France, thanks to the active participation of health professionals, and confirms the striking increase in the prescription of oxycodone and the misuse of fentanyl.
镇痛药是全球使用最广泛的药物之一。法国药物警戒网络（FAN）开展了麻醉性镇痛药及安全处方（ASOS）调查，以评估麻醉性镇痛药防篡改处方表在医学界的传播情况，以及处方的性质和演变。在概述FAN的任务后，本文将描述法国接受麻醉性镇痛药治疗的人群、他们的治疗适应症以及自2007年以来数据的变化情况。
进行了一项横断面、全国性、多中心调查研究，包括2007年至2023年每年在全国1500家随机抽取的配药药房样本中进行的调查。
患者的平均年龄在研究期间保持稳定（2007年为63.2岁，2023年为67.6岁），大多数患者为女性（约60%）。大多数处方涉及吗啡、羟考酮和芬太尼。吗啡和芬太尼是开具阿片类镇痛药的参考分子，但2007年至2015年间羟考酮处方的急剧增加影响了它们的使用。癌症和风湿性疼痛是主要适应症，近年来神经学适应症有所增加。对芬太尼和羟考酮的关注突出了在其他调查中难以识别的滥用模式。
这项研究展示了在法国卫生专业人员的积极参与下麻醉性阿片类药物的处方情况，并证实了羟考酮处方的显著增加以及芬太尼的滥用。
