Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana, RS, Brazil.
Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana, RS, Brazil; Applied Neuromechanics Group, Laboratory of Neuromechanics, Universidade Federal do Pampa, Uruguaiana, RS, Brazil.
Physiol Behav. 2022 Jan 1;243:113631. doi: 10.1016/j.physbeh.2021.113631. Epub 2021 Oct 29.
Alzheimer's disease affects thousands of people worldwide. Alternatives aiming to prevent the disease or reduce its symptoms include different physical exercise configurations. Here we investigate the potential of concurrent exercise to prevent recognition memory deficits in an Alzheimer's disease-like model induced by the hippocampal beta-amyloid (Aβ) injection in Wistar rats. We demonstrate that the concurrent exercise, which included running and strength exercises performed in the same exercise session, is ineffective in preventing recognition memory deficits in the Aβ rats. Besides, higher levels of reactive oxygen species were found in the concurrent exercise group's hippocampus. The running exercise administrated alone prevented recognition memory impairments.
阿尔茨海默病影响着全球成千上万的人。为了预防这种疾病或减轻其症状，人们尝试了各种方法，其中包括不同的体育锻炼方式。在这里，我们研究了在 Wistar 大鼠的海马β-淀粉样蛋白（Aβ）注射诱导的阿尔茨海默病样模型中，同时进行运动是否具有预防认知记忆缺陷的潜力。我们的研究结果表明，同时进行的运动（包括跑步和力量训练）并不能预防 Aβ 大鼠的认知记忆缺陷，而且在同时进行运动的大鼠海马体中发现了更高水平的活性氧。单独进行跑步运动则可以预防认知记忆障碍。
