Federal University of Pampa, campus Uruguaiana, Uruguaiana, RS, Brazil.
Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
J Alzheimers Dis. 2021;83(1):143-154. doi: 10.3233/JAD-210424.
Alzheimer's disease (AD) is characterized by the accumulation of the amyloid-β peptide in the brain, leading to early oxidative stress and neurotoxicity. It has been suggested that physical exercise could be beneficial in preventing AD, but studies with multicomponent training are scanty.
Verify the effects of multicomponent exercise training to prevent deficits in recognition memory related to Aβ neurotoxicity.
We subjected Wistar rats to multicomponent training (including aerobic and anaerobic physical exercise and cognitive exercise) and then infused amyloid-β peptide into their hippocampus.
We show that long-term multicomponent training prevents the amyloid-β-associated neurotoxicity in the hippocampus. It reduces hippocampal lipid peroxidation, restores antioxidant capacity, and increases glutathione levels, finally preventing recognition memory deficits.
Multicomponent training avoids memory deficits related to amyloid-β neurotoxicity on an animal model.
阿尔茨海默病（AD）的特征是大脑中淀粉样蛋白-β肽的积累，导致早期氧化应激和神经毒性。有人认为，体育锻炼可能有益于预防 AD，但多成分训练的研究很少。
验证多成分运动训练预防与 Aβ神经毒性相关的识别记忆缺陷的效果。
我们让 Wistar 大鼠进行多成分训练（包括有氧和无氧体育锻炼以及认知锻炼），然后将淀粉样蛋白-β肽注入其海马体。
我们表明，长期多成分训练可预防海马体与淀粉样蛋白-β相关的神经毒性。它降低了海马体的脂质过氧化，恢复了抗氧化能力，并增加了谷胱甘肽水平，最终防止了识别记忆缺陷。
多成分训练可避免动物模型中与淀粉样蛋白-β神经毒性相关的记忆缺陷。
