de Andrade Santos F O, Passos A A, Arida R M, Teixeira-Machado L
Ricardo Mario Arida, Physiology Department, Federal University of São Paulo, SP, Brazil,
J Prev Alzheimers Dis. 2024;11(4):998-1012. doi: 10.14283/jpad.2024.75.
Alzheimer's disease (AD) is among common cause of dementia. Complementary therapies, such as resistance exercise (RE), have been proposed as an alternative for the treatment of AD. We performed a systematic review and meta-analysis to investigate the effects of RE on the cognitive function of AD animal models and their physiological mechanisms.
This review was submitted to PROSPERO (CRD42019131266) and was done according to PRISMA checklist. Four databases were used in the search: MEDLINE/PUBMED, SCOPUS, Web of Science and Google Scholar. We used SYRCLE and CAMAREDES to assess the risk of bias and methodological quality. We calculated the standardized mean difference using 95% confidence intervals and considered the random effects model and p < 0.05 to determine significance.
A total of 1,807 studies were founded, and after the selection process, only 11 studies were included in this review and 8 studies were included for meta-analysis. Four studies applied RE before AD induction, 7 studies applied RE after AD induction or in the AD condition. All studies included 550 adult and older animals weighing 25-280g. Our analysis revealed that RE had a positive effect on memory in AD animal models but did not show a significant impact on anxiety.
RE performed four or six weeks, more than three days a week, had a significant protective effect on memory. The included studies had a high risk of bias and moderate methodological quality. Therefore, RE can be a potential strategy for preventing cognitive decline in animal models.
阿尔茨海默病（AD）是痴呆症的常见病因之一。诸如抗阻运动（RE）等补充疗法已被提议作为治疗AD的一种替代方法。我们进行了一项系统评价和荟萃分析，以研究抗阻运动对AD动物模型认知功能及其生理机制的影响。
本评价已提交至国际系统评价注册库（PROSPERO，注册号：CRD42019131266），并按照系统评价和荟萃分析的首选报告项目（PRISMA）清单进行。检索使用了四个数据库：医学文献数据库/医学期刊数据库（MEDLINE/PUBMED）、Scopus数据库、科学引文索引数据库（Web of Science）和谷歌学术搜索。我们使用SYRCLE和CAMAREDES评估偏倚风险和方法学质量。我们使用95%置信区间计算标准化均值差，并采用随机效应模型和p<0.05来确定显著性。
共检索到1807项研究，经过筛选过程，本评价仅纳入了11项研究，荟萃分析纳入了8项研究。4项研究在诱导AD之前应用抗阻运动，7项研究在诱导AD之后或在AD状态下应用抗阻运动。所有研究共纳入550只体重在25 - 280克的成年及老年动物。我们的分析表明，抗阻运动对AD动物模型的记忆有积极影响，但对焦虑没有显著影响。
每周进行三天以上、持续四至六周的抗阻运动对记忆有显著的保护作用。纳入的研究存在较高的偏倚风险和中等的方法学质量。因此，抗阻运动可能是预防动物模型认知衰退的一种潜在策略。
