Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia.
Centre for Mental Health, Faculty of Health, Arts and Design, School of Health Sciences, Swinburne University, Melbourne, Australia; Department of Psychiatry, St Vincent's Hospital, VIC, Australia.
J Affect Disord. 2022 Feb 1;298(Pt A):166-172. doi: 10.1016/j.jad.2021.10.107. Epub 2021 Oct 27.
The aim of this cross-sectional study was to investigate dispositional mindfulness and its association with depression and manic tendencies, and subjective life quality in bipolar disorder (BD). Furthermore, this study sought to examine the potential mediating effects of emotion regulation difficulties on these relationships.
Twenty-eight healthy controls (HC) and 66 clinically stable outpatients with a DSM-IV-TR diagnosis of BD completed the Mindfulness Attention Awareness Scale (MAAS), Difficulties in Emotion Regulation Scale (DERS), Seven Up (7 Up) Seven Down (7 Down) and the Quality of Life in Bipolar Disorder Questionnaire (QoL.BD). These variables were compared between groups and entered into a series of mediation analyzes using PROCESS in the BD group only.
Lower MAAS scores were detected amongst the BD patients compared to HCs. Lower MAAS scores in BD patients predicted higher 7 Up, 7 Down and lower QoL.BD scores. For the 7 Down and QoL.BD, the associations were completely mediated by DERS scores, with difficulties in strategy use and emotional clarity mediating the association between mindfulness and depressive tendencies and quality of life, respectively. No significant direct or indirect effects were detected for the 7 Up model.
The cross-sectional design precludes causal inference. The MAAS conceptualises mindfulness as unidimensional. Self-report scales of depressive and manic tendencies utilised.
This study detected a significant association between dispositional mindfulness and depressive tendencies and life quality in BD, and found that these associations were influenced by emotion regulation difficulties. These findings encourage further investigation of mindfulness-based interventions in BD.
本横断面研究旨在探讨特质正念及其与双相障碍（BD）患者的抑郁和躁狂倾向以及主观生活质量的关系。此外，本研究还探讨了情绪调节困难在这些关系中的潜在中介作用。
28 名健康对照者（HC）和 66 名符合 DSM-IV-TR 诊断标准的临床稳定 BD 门诊患者完成了正念注意觉察量表（MAAS）、情绪调节困难量表（DERS）、7 Up-7 Down 测验和双相障碍生活质量问卷（QoL.BD）。比较了两组间的这些变量，并仅在 BD 组中使用 PROCESS 进行了一系列中介分析。
BD 患者的 MAAS 得分低于 HC。BD 患者的 MAAS 得分越低，7 Up、7 Down 和 QoL.BD 的得分越低。对于 7 Down 和 QoL.BD，DERS 得分完全中介了两者之间的关联，策略使用和情绪清晰方面的困难分别中介了正念与抑郁倾向和生活质量之间的关联。对于 7 Up 模型，未检测到显著的直接或间接影响。
横断面设计不能进行因果推断。MAAS 将正念概念化为单一维度。使用了自评的抑郁和躁狂倾向量表。
本研究检测到 BD 患者的特质正念与抑郁倾向和生活质量之间存在显著关联，并发现这些关联受情绪调节困难的影响。这些发现鼓励进一步研究正念为基础的干预措施在 BD 中的应用。
