鸢尾根茎中异黄酮糖苷的长链脂肪酸酰化衍生物。
Long-chain fatty acid acylated derivatives of isoflavone glycosides from the rhizomes of Iris domestica.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100050, People's Republic of China.
出版信息
Phytochemistry. 2022 Jan;193:112977. doi: 10.1016/j.phytochem.2021.112977. Epub 2021 Oct 27.
Six undescribed long-chain fatty acid esters of isoflavone glycosides were obtained from the rhizomes of Iris domestica (L.). Their structures were elucidated by comprehensive spectroscopic data, alkaline hydrolysis, and acid hydrolysis. This is the first report of the long-chain (C-C) fatty acid derivatives of isoflavone glycosides from natural products. Belamcandnoate B and D exhibited moderate cytotoxic activities against HCT-116, HepG2, and BGC823 cell lines with IC values of 1.69-6.86 μM. Belamcandnoate B and E exhibited 72.27 and 58.98% inhibitory activities, respectively, against Fe/cysteine-induced liver microsomal lipid peroxidation at a concentration of 10 μM.
从鸢尾属植物的根茎中获得了六种未被描述的异黄酮糖苷的长链脂肪酸酯。通过综合光谱数据、碱性水解和酸性水解确定了它们的结构。这是天然产物中异黄酮糖苷的长链（C-C）脂肪酸衍生物的首次报道。贝兰坎德酯 B 和 D 对 HCT-116、HepG2 和 BGC823 细胞系表现出中等的细胞毒性活性，IC 值为 1.69-6.86 μM。贝兰坎德酯 B 和 E 在 10 μM 浓度下对 Fe/半胱氨酸诱导的肝微粒体脂质过氧化的抑制率分别为 72.27%和 58.98%。
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