从射干根茎中提取的具有抗炎和细胞毒性活性的酚类成分。

Phenolic constituents with anti-inflammatory and cytotoxic activities from the rhizomes of Iris domestica.

作者信息

Liu Kai-Dong, Yang Wan-Qi, Dai Ming-Zhu, Xu Yong, Qin Yun-Peng, Dong Ying-Ying, Fu Jiang, Qu Jing

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China.

出版信息

Phytochemistry. 2022 Nov;203:113370. doi: 10.1016/j.phytochem.2022.113370. Epub 2022 Aug 14.

DOI:10.1016/j.phytochem.2022.113370

PMID:35977602

Abstract

Four undescribed flavonoid glucosides (iridins B-C, tectoridin A and ampelopsinin A); one undescribed phenolic glucoside (diplostephioside B); one undescribed phenolic compound (phenanthrenetriol A); and seventeen known compounds were isolated from the rhizomes of Iris domestica. The chemical structures of the undescribed compounds were established by spectroscopic/spectrometric data interpretation using HRESIMS, NMR, and ECD. Tectoridin A, nigricin A and naringenin exhibited anti-inflammatory activities with inhibition rates of 53.71%, 57.68% and 88.71%, respectively, against the NF-κB signaling pathway at a concentration of 10 μM. 4'-O-methylnyasol (10 μM) exhibited 84.91% antiproliferative activity against the K562 human leukemia cell line with an IC value of 4.20 μM.

摘要

从鸢尾的根茎中分离出4种未描述的黄酮类葡萄糖苷（鸢尾苷B - C、鸢尾黄素A和蛇葡萄素A）；1种未描述的酚类葡萄糖苷（双柱菊苷B）；1种未描述的酚类化合物（菲三醇A）；以及17种已知化合物。通过使用高分辨电喷雾电离质谱（HRESIMS）、核磁共振（NMR）和电子圆二色谱（ECD）对光谱/光谱数据进行解释，确定了未描述化合物的化学结构。鸢尾黄素A、黑麦草素A和柚皮素在浓度为10 μM时，对NF-κB信号通路的抗炎活性抑制率分别为53.71%、57.68%和88.71%。4'-O-甲基尼亚索（10 μM）对K562人白血病细胞系表现出84.91%的抗增殖活性，半数抑制浓度（IC）值为4.20 μM。