抗生素治疗下生存的定量生物学。

Quantitative biology of survival under antibiotic treatments.

机构信息

Racah Institute of Physics, Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel.

出版信息

Curr Opin Microbiol. 2021 Dec;64:139-145. doi: 10.1016/j.mib.2021.10.007. Epub 2021 Oct 26.

DOI:10.1016/j.mib.2021.10.007

Abstract

The mathematical formulation for the dynamics of growth reduction and/or killing under antibiotic treatments has a long history. Even before the extensive use of antibiotics, attempts to model the killing dynamics of biocides were made [1]. Here, we review relatively simple quantitative formulations of the two main modes of survival under antibiotics, resistance and tolerance, as well as their heterogeneity in bacterial populations. We focus on the two main types of heterogeneity that have been described: heteroresistance and antibiotic persistence, each linked to the variation in a different parameter of the antibiotic response dynamics. Finally, we review the effects on survival of combining resistance and tolerance mutations as well as on the mode and tempo of evolution under antibiotic treatments.

摘要

抗生素治疗下生长减少和/或杀灭动力学的数学公式由来已久。甚至在抗生素广泛使用之前，就已经有人尝试建立杀菌剂的杀菌动力学模型[1]。在这里，我们回顾了抗生素作用下两种主要生存模式（耐药性和耐受性）的相对简单的定量公式，以及它们在细菌群体中的异质性。我们重点介绍了已经描述的两种主要异质性类型：异质性耐药性和抗生素持续性，它们分别与抗生素反应动力学的不同参数的变化有关。最后，我们回顾了耐药性和耐受性突变的组合对生存的影响，以及抗生素治疗下的进化模式和速度。