Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, 14155-6453 Tehran, Iran.
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, 5166616471 Tabriz, Iran.
Comp Immunol Microbiol Infect Dis. 2021 Dec;79:101714. doi: 10.1016/j.cimid.2021.101714. Epub 2021 Oct 21.
The primary cause of contagious ecthyma is the orf virus, the parapoxvirus prototype. It is a viral problem observed in goat and sheep flocks in Iran, causing economic loss. Orf is a zoonosis with little epidemiological investigation present in Iran. The current research aims at determining the status of this virus, and a PCR was used as a confirmatory instrument. We sampled 668 goats and sheep and various breeding systems. Besides, the orf prevalence was studied, and vaccination efficacy was determined. Moreover, the potential risk factors surveyed for infection with ecthyma were identified. Samples were taken from goat and sheep flocks in the present cross-sectional research, and PCR was used for testing orf DNA. A checklist including animals' general information was completed. Data were analyzed using univariate tests (chi-square and t-tests) and multivariable binary logistic regression analysis. Three hundred one (45%) goats and sheep detected orf DNA. The age of 70% of positive cases was below one month. Ecthyma infection was significantly higher in imported breeds (87.3%) than indigenous (39.3%). Ninety-six percent of infected goats and sheep in the present work were not vaccinated against ecthyma. The high prevalence of the orf virus was confirmed among goat and sheep flocks in Iran. It is necessary to train ranchers regarding sanitary actions, quarantine, and application of orf vaccination plans.
接触性传染性脓疱的主要病因是羊口疮病毒，即副痘病毒原型。这是一种在伊朗山羊和绵羊群中观察到的病毒性问题，会造成经济损失。羊口疮是一种在伊朗进行的流行病学调查较少的人畜共患病。本研究旨在确定该病毒的现状，并使用 PCR 作为确认工具。我们对 668 只山羊和绵羊以及各种繁殖系统进行了采样。此外，还研究了羊口疮的流行情况，并确定了疫苗接种的效果。还确定了感染脓疱的潜在危险因素。在本横断面研究中，从山羊和绵羊群中采集样本，并使用 PCR 检测羊口疮 DNA。完成了一份包含动物一般信息的检查表。使用单变量检验（卡方检验和 t 检验）和多变量二项逻辑回归分析对数据进行分析。在 301 只（45%）山羊和绵羊中检测到羊口疮 DNA。阳性病例中 70%的年龄低于一个月。进口品种（87.3%）的脓疱感染明显高于本地品种（39.3%）。在本研究中，感染脓疱的 96%的山羊和绵羊未接种过羊口疮疫苗。在伊朗的山羊和绵羊群中证实了羊口疮病毒的高流行率。有必要对牧场主进行有关卫生措施、检疫和羊口疮疫苗接种计划的培训。
