Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Vet Med Sci. 2024 Jul;10(4):e1516. doi: 10.1002/vms3.1516.
Papilloma DNA viruses are one of the viruses that cause skin lesions in ruminants.
The clinical, histopathological and molecular characteristics of cutaneous papilloma in ruminants in Iran are to be investigated in this study.
Samples were collected from 19 small ruminants (5 sheep and 14 goats) with various papillomatosis lesions. The samples taken were studied with histopathological and molecular techniques.
In clinical terms, the lesions appeared in different sizes, ranging from 0.5 to 11 cm, and the cauliflower exophytic masses appeared in other parts of the animal's body. In the limbs, most papilloma lesions have been seen (42.1%). In histopathological examination, perinuclear vacuolation epidermal granule layer with various degrees of hypergranulosis, hyperkeratosis, acanthosis, orthokeratosis and parakeratosis were seen. Moreover, all the suspected samples were positive for papillomavirus using the polymerase chain reaction technique.
Although the prevalence of papillomaviruses in Iranian sheep and goats is low, it seems necessary to distinguish them from other viral skin diseases, such as cutaneous contagious ecthyma, using molecular techniques and histopathology.
乳头瘤 DNA 病毒是引起反刍动物皮肤损伤的病毒之一。
本研究旨在调查伊朗反刍动物皮肤乳头瘤的临床、组织病理学和分子特征。
从 19 只患有各种乳头瘤病的小反刍动物（5 只绵羊和 14 只山羊）中采集样本。采集的样本通过组织病理学和分子技术进行研究。
从临床角度来看，病变大小不一，从 0.5 厘米到 11 厘米不等，动物身体的其他部位出现了菜花状外生性肿块。在四肢中，最常见的是乳头瘤病变（42.1%）。在组织病理学检查中，可见核周空泡化的颗粒层表皮，有不同程度的过度角化、角化过度、棘皮症、正角化和不全角化。此外，所有疑似样本均通过聚合酶链反应技术检测到乳头瘤病毒呈阳性。
尽管在伊朗绵羊和山羊中，乳头瘤病毒的流行率较低，但似乎有必要使用分子技术和组织病理学将其与其他病毒性皮肤病（如传染性接触性脓疱性皮炎）区分开来。
