Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New Area, Shanghai 201203, China.
School of pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Phytomedicine. 2021 Dec;93:153799. doi: 10.1016/j.phymed.2021.153799. Epub 2021 Oct 11.
Natural medicines have a long history in the prevention and treatment of various diseases in East Asian region, especially in China. Modern research has proved that the pharmacological effects of numerous natural medicines involve the participation of ubiquitin proteasome system (UPS). UPS can degrade the unwanted and damaged proteins widely distributed in the nucleus and cytoplasm of various eukaryotes.
The objective of the present study was to review and discuss the regulatory effects of natural products and extracts on proteasome components, which may help to find new proteasome regulators for drug development and clinical applications.
The related information was compiled using the major scientific databases, such as CNKI, Elsevier, ScienceDirect, PubMed, SpringerLink, Wiley Online, and GeenMedical. The keywords "natural product" and "proteasome" were applied to extract the literature. Nature derived extracts, compounds and their derivatives involved in proteasome regulation were included, and the publications related to synthetic proteasome agents were excluded.
The pharmacological effects of more than 80 natural products and extracts derived from phytomedicines related to the proteasome regulation were reviewed. These natural products were classified according to their chemical properties. We also summarized some laws of action of natural products as proteasome regulators in the treatment of diseases, and listed the action characteristics of the typical natural products.
Natural products derived from nature can induce the degradation of damaged proteins through UPS or act as regulators to directly regulate the activity of proteasome. But few proteasome modulators are applied clinically. Summary of known rules for proteasome modulators will contribute to discover, modify and synthesize more proteasome modulators for clinical applications.
天然药物在东亚地区的各种疾病的预防和治疗中有着悠久的历史，尤其是在中国。现代研究已经证明，许多天然药物的药理作用涉及泛素蛋白酶体系统（UPS）的参与。UPS 可以降解广泛分布于各种真核生物的核和细胞质中的不需要的和受损的蛋白质。
本研究旨在综述和讨论天然产物和提取物对蛋白酶体成分的调节作用，以期为药物开发和临床应用寻找新的蛋白酶体调节剂。
使用主要科学数据库，如中国知网、爱思唯尔、ScienceDirect、PubMed、施普林格链接、威利在线和医脉通等，编译相关信息。使用“天然产物”和“蛋白酶体”等关键词提取文献。纳入涉及蛋白酶体调节的天然来源提取物、化合物及其衍生物，排除与合成蛋白酶体剂相关的出版物。
综述了 80 多种与蛋白酶体调节相关的植物药来源的天然产物和提取物的药理作用。这些天然产物根据其化学性质进行分类。我们还总结了一些天然产物作为蛋白酶体调节剂在治疗疾病中的作用规律，并列出了典型天然产物的作用特点。
天然产物可以通过 UPS 诱导受损蛋白质的降解，或者作为调节剂直接调节蛋白酶体的活性。但临床上应用的蛋白酶体调节剂很少。对已知蛋白酶体调节剂规则的总结将有助于发现、修饰和合成更多用于临床应用的蛋白酶体调节剂。
