Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vassileos Constantinou Ave., Athens, 11635, Greece; Department of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 41500, Larisa, Greece.
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, Athens, 15771, Greece.
Redox Biol. 2021 May;41:101897. doi: 10.1016/j.redox.2021.101897. Epub 2021 Feb 17.
The ubiquitin-proteasome system (UPS) is a key player in the maintenance of cellular protein homeostasis (proteostasis). Since proteasome function declines upon aging leading to the acceleration of its progression and the manifestation of age-related pathologies, many attempts have been performed towards proteasome activation as a strategy to promote healthspan and longevity. The marine environment hosts a plethora of organisms that produce a vast array of primary and secondary metabolites, the majority of which are unique, exhibiting a wide spectrum of biological activities. The fact that these biologically important compounds are also present in edible marine organisms has sparked the interest for elucidating their potential health-related applications. In this review, we focus on the antioxidant, anti-aging, anti-aggregation and anti-photoaging properties of various marine constituents. We further discuss representatives of marine compounds classes with regard to their potential (direct or indirect) action on UPS components that could serve as UPS modulators and exert beneficial effects on conditions such as oxidative stress, aging and age-related diseases.
泛素-蛋白酶体系统 (UPS) 是维持细胞蛋白质内稳态 (proteostasis) 的关键因素。由于蛋白酶体功能随着年龄的增长而下降，导致其进展加速和与年龄相关的病理表现，因此许多人尝试激活蛋白酶体作为促进健康寿命和长寿的策略。海洋环境中栖息着大量的生物体，它们产生大量的初级和次级代谢产物，其中大多数是独特的，具有广泛的生物活性。这些具有生物重要性的化合物也存在于可食用的海洋生物中，这激发了人们对阐明其潜在健康相关应用的兴趣。在这篇综述中，我们重点讨论了各种海洋成分的抗氧化、抗衰老、抗聚集和抗光老化特性。我们还进一步讨论了海洋化合物类别的代表性化合物，它们可能通过直接或间接作用于 UPS 成分作为 UPS 调节剂，并对氧化应激、衰老和与年龄相关的疾病等条件产生有益影响。
