Alshurafa Awni, Abu-Tineh Mohammad, Ibrahim Feryal A, Petkar Mahir, Yassin Mohamed A
Hematology Department, Hamad Medical Corporation, Doha, Qatar.
Department of Laboratory Medicine and Pathology/Haematopathology, Hamad Medical Corporation, Doha, Qatar.
Case Rep Oncol. 2023 Feb 10;16(1):62-68. doi: 10.1159/000529347. eCollection 2023 Jan-Dec.
Mastocytosis is a heterogeneous group of disorders in which mast cells exhibit clonal proliferation that infiltrates one or more organs. In cutaneous mastocytosis, the mast cells infiltrate the skin only, whereas systemic mastocytosis is diagnosed when at least one extra-cutaneous site is involved, with or without the skin being affected. Given the rarity of mastocytosis and the fact that skin rash can be a manifestation of different conditions and many clinicians are not familiar with this disorder, an accurate diagnosis may be delayed. We report a delayed diagnosis of indolent systemic mastocytosis in a 40-year-old gentleman who had been complaining of an unexplained skin rash for 6 years.
肥大细胞增多症是一组异质性疾病，其中肥大细胞表现出克隆性增殖并浸润一个或多个器官。在皮肤肥大细胞增多症中，肥大细胞仅浸润皮肤，而当至少一个皮肤外部位受累，无论皮肤是否受影响时，则诊断为系统性肥大细胞增多症。鉴于肥大细胞增多症罕见，且皮疹可能是不同病症的表现，许多临床医生并不熟悉这种疾病，因此准确诊断可能会延迟。我们报告了一例40岁男性惰性系统性肥大细胞增多症的延迟诊断病例，该患者主诉不明原因皮疹6年。
