Department of Public Health, Kitasato University School of Medicine, 1-15-1 Kitazato, Minami-ku, Sagamihara, 252-0374, Japan.
Department of Mental Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.
BMC Public Health. 2021 Oct 29;21(1):1960. doi: 10.1186/s12889-021-12059-y.
Although sedentary behavior is associated with the onset of major depressive disorder, it remains unclear whether sedentary behavior at work increases the risk of depression. The present study used the Bayesian approach to investigate the association between sitting time at work and the onset of major depressive episode (MDE).
A 1-year prospective cohort study was conducted among 233 Japanese workers without MDE (response rate: 4.3%). MDE onset was assessed using the self-reported WHO Composite International Diagnostic Interview version 3.0. A Bayesian Cox proportional hazard model was used to estimate the hazard ratio (HR) between long sitting time at work and MDE onset.
A total of 231 workers were included in the analysis. During the follow-up, 1621 person-months were observed, and six participants experienced MDE onset. Incident rates per months were 0.34, 0.11, and 1.02% in short (< 7.2 h per day), medium (7.2-9.5 h), and long (9.5+ h) sitting time at work, respectively. The estimated median posterior probability distribution of the HR of long sitting time was 3.00 (95% highest density interval [HDI]: 0.73-12.03). The estimated median remained positive after adjustment for physical activity level and other covariates (HR = 2.11, 95% HDI: 0.42-10.22). The 10-base Bayesian factor for H1 (HR = 1.00) compared with the alternatives (H0, HR = 1.00) was 0.68 in the adjusted model. The analysis, which treated sitting time at work as a continuous variable, estimated that the median of the posterior probability distribution of the HR of sitting time was 0.79 (95% HDI: 0.58-1.07. The 10-base Bayesian factor was 2.73 in the linear association.
Long sitting time at work (9.5+ h per day) might be associated with MDE onset among workers. However, the linear association indicated conflicting results. Non-linear associations between sitting time and MDE onset might explain this inconsistency. The evidence for an adverse association between sitting time at work and MDE onset remains inconclusive.
尽管久坐行为与重度抑郁症的发病有关，但目前尚不清楚工作中的久坐行为是否会增加抑郁的风险。本研究采用贝叶斯方法探讨了工作时的坐姿时间与重度抑郁发作（MDE）发病之间的关系。
对 233 名无 MDE 的日本工人进行了为期 1 年的前瞻性队列研究（应答率：4.3%）。使用世界卫生组织复合国际诊断访谈第 3.0 版自报告评估 MDE 发病情况。采用贝叶斯 Cox 比例风险模型估计工作中长时间坐姿与 MDE 发病之间的风险比（HR）。
共有 231 名工人纳入分析。在随访期间，观察到 1621 个人月，6 名参与者发生 MDE 发作。每月的发病率分别为短时间（每天<7.2 小时）、中等时间（7.2-9.5 小时）和长时间（9.5+小时）坐姿工作时的 0.34%、0.11%和 1.02%。长时间坐姿的 HR 的估计中位后验概率分布为 3.00（95%最高密度区间[HDI]：0.73-12.03）。在调整体力活动水平和其他协变量后，估计中位数仍为阳性（HR=2.11，95%HDI：0.42-10.22）。调整模型中，H1（HR=1.00）与替代方案（H0，HR=1.00）的 10 个基数贝叶斯因子为 0.68。将坐姿时间视为连续变量的分析估计，坐姿时间的 HR 后验概率分布中位数为 0.79（95%HDI：0.58-1.07）。10 个基数贝叶斯因子在线性关联中为 2.73。
工作时的长时间坐姿（每天 9.5 小时以上）可能与工人的 MDE 发病有关。然而，线性关联的结果存在冲突。坐姿与 MDE 发病之间的非线性关联可能解释了这种不一致。坐姿与工作时 MDE 发病之间的不良关联的证据仍不明确。
