足细胞衰老：为什么以及如何变老很重要。
Podocyte Aging: Why and How Getting Old Matters.
机构信息
Division of Nephrology, University of Washington, Seattle, Washington.
Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, Washington.
出版信息
J Am Soc Nephrol. 2021 Nov;32(11):2697-2713. doi: 10.1681/ASN.2021050614.
The effects of healthy aging on the kidney, and how these effects intersect with superimposed diseases, are highly relevant in the context of the population's increasing longevity. Age-associated changes to podocytes, which are terminally differentiated glomerular epithelial cells, adversely affect kidney health. This review discusses the molecular and cellular mechanisms underlying podocyte aging, how these mechanisms might be augmented by disease in the aged kidney, and approaches to mitigate progressive damage to podocytes. Furthermore, we address how biologic pathways such as those associated with cellular growth confound aging in humans and rodents.
健康老龄化对肾脏的影响，以及这些影响与叠加疾病的相互作用，在人口寿命不断延长的背景下具有重要意义。终末分化的肾小球上皮细胞——足细胞的衰老相关变化对肾脏健康产生不利影响。本文讨论了足细胞衰老的分子和细胞机制，以及这些机制如何在老年肾脏疾病中增强，以及减轻足细胞进行性损伤的方法。此外，我们还探讨了与细胞生长相关的生物途径等如何混淆人类和啮齿动物的衰老。
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