Department of Biochemistry, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.
Department of Biophysics, Bose Institute, P 1/12, CIT Scheme VII M, Kolkata, West Bengal, 700054, India.
Mol Cell Biochem. 2022 Feb;477(2):345-361. doi: 10.1007/s11010-021-04281-4. Epub 2021 Oct 30.
The relative contribution of mitochondrial respiration and subsequent energy production in malignant cells has remained controversial to date. Enhanced aerobic glycolysis and impaired mitochondrial respiration have gained more attention in the metabolic study of cancer. In contrast to the popular concept, mitochondria of cancer cells oxidize a diverse array of metabolic fuels to generate a majority of the cellular energy by respiration. Several mitochondrial respiratory chain (MRC) subunits' expressions are critical for the growth, metastasis, and cancer cell invasion. Also, the assembly factors, which regulate the integration of individual MRC complexes into native super-complexes, are upregulated in cancer. Moreover, a series of anti-cancer drugs function by inhibiting respiration and ATP production. In this review, we have specified the roles of mitochondrial fuels, MRC subunits, and super-complex assembly factors that promote active respiration across different cancer types and discussed the potential roles of MRC inhibitor drugs in controlling cancer.
迄今为止，线粒体呼吸及其后续能量产生在恶性肿瘤细胞中的相对贡献仍存在争议。在癌症的代谢研究中，人们越来越关注增强的有氧糖酵解和受损的线粒体呼吸。与流行的观点相反，癌细胞的线粒体氧化多种代谢燃料，通过呼吸产生大部分细胞能量。几种线粒体呼吸链（MRC）亚基的表达对于肿瘤细胞的生长、转移和侵袭至关重要。此外，调节单个 MRC 复合物整合到天然超复合物中的组装因子在癌症中上调。此外，一系列抗癌药物通过抑制呼吸和 ATP 产生来发挥作用。在这篇综述中，我们详细说明了促进不同类型癌症中活跃呼吸的线粒体燃料、MRC 亚基和超复合物组装因子的作用，并讨论了 MRC 抑制剂药物在控制癌症方面的潜在作用。
