Binagui-Casas Anahí, Dias André, Guillot Charlène, Metzis Vicki, Saunders Dillan
Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156, Oeiras, Portugal.
Curr Opin Cell Biol. 2021 Dec;73:133-140. doi: 10.1016/j.ceb.2021.08.003. Epub 2021 Oct 28.
The development of the vertebrate body axis relies on the activity of different populations of axial progenitors, including neuromesodermal progenitors. Currently, the term 'Neuromesodermal progenitors' is associated with various definitions. Here, we use distinct terminologies to highlight advances in our understanding of this cell type at both the single-cell and population levels. We discuss how these recent insights prompt new opportunities to address a range of biomedical questions spanning cancer metastasis, congenital disorders, cellular metabolism, regenerative medicine, and evolution. Finally, we outline some of the major unanswered questions and propose future directions at the forefront of neuromesodermal research.
脊椎动物身体轴的发育依赖于不同群体的轴向祖细胞的活动，包括神经中胚层祖细胞。目前，“神经中胚层祖细胞”这一术语有多种定义。在此，我们使用不同的术语来突出我们在单细胞和群体水平上对这种细胞类型理解的进展。我们讨论了这些最新见解如何带来新的机会，以解决一系列生物医学问题，涵盖癌症转移、先天性疾病、细胞代谢、再生医学和进化。最后，我们概述了一些主要的未解决问题，并提出了神经中胚层研究前沿的未来方向。
