Department of Clinical Biochemistry, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Lipids Health Dis. 2021 Oct 30;20(1):147. doi: 10.1186/s12944-021-01579-6.
Lipid levels in blood have decreased considerably during the past decades in the general population partly due to use of statins. This study aims to investigate the trends in lipid levels between 2001 and 2018 in a statin-free population from primary health care, overall and by sex and age.
In a cohort of 634,119 patients from general practice with no diagnoses or medical treatments that affected lipid levels of total cholesterol (TC; n = 1,574,339) between 2001 and 2018 were identified. Similarly, measurements of low-density lipoprotein cholesterol (LDL-C; n = 1,302,440), high-density lipoprotein cholesterol (HDL-C; n = 1,417,857) and triglycerides (TG; n = 1,329,477) were identified.
Mean TC decreased from 5.64 mmol/L (95% CI: 5.63-5.65) in 2001 to 5.17 mmol/L (95% CI: 5.16-5.17) in 2018 while LDL-C decreased from 3.67 mmol/L (95% CI: 3.66-3.68) to 3.04 mmol/L (95% CI: 3.03-3.04). Women aged 70-74 years experienced the largest decreases in TC levels corresponding to a decrease of 0.7 mmol/L. The decrease in LDL-C levels was most pronounced in men ≥85 years with a decrease of 0.9 mmol/L. For both genders, TC and LDL-C levels increased with advancing age until around age 50. After menopause the women had higher TC and LDL-C levels than the men. The median (geometric mean) TG level decreased by 0.4 mmol/L from 2001 to 2008, after which it increased slightly by 0.1 mmol/L until 2018. During life the TG levels of the men were markedly higher than the women's until around age 65-70. HDL-C levels showed no trend during the study period.
The levels of TC and LDL-C decreased considerably in a statin-free population from primary health care from 2001 to 2018. These decreases were most pronounced in the elderly population and this trend is not decelerating. For TG, levels have started to increase, after an initial decrease.
在普通人群中，由于使用他汀类药物，血脂水平在过去几十年中大幅下降。本研究旨在调查来自初级保健的他汀类药物免费人群中，2001 年至 2018 年期间血脂水平的变化趋势，包括总体水平以及按性别和年龄的变化趋势。
在一个没有诊断或影响总胆固醇（TC；n=1574339）血脂水平的医学治疗的普通诊所患者队列中，确定了 634119 名患者（n=634119）。同样，还确定了低密度脂蛋白胆固醇（LDL-C；n=1302440）、高密度脂蛋白胆固醇（HDL-C；n=1417857）和甘油三酯（TG；n=1329477）的测量值。
TC 平均值从 2001 年的 5.64mmol/L（95%CI：5.63-5.65）降至 2018 年的 5.17mmol/L（95%CI：5.16-5.17），LDL-C 从 3.67mmol/L（95%CI：3.66-3.68）降至 3.04mmol/L（95%CI：3.03-3.04）。70-74 岁的女性 TC 水平下降最大，下降 0.7mmol/L。男性中，TC 和 LDL-C 水平随着年龄的增长而增加，直到 50 岁左右。绝经后，女性的 TC 和 LDL-C 水平高于男性。TG 中位数（几何均数）从 2001 年到 2008 年下降了 0.4mmol/L，之后略有增加 0.1mmol/L，直到 2018 年。在整个生命过程中，男性的 TG 水平明显高于女性，直到大约 65-70 岁。HDL-C 水平在研究期间没有趋势。
在 2001 年至 2018 年期间，来自初级保健的他汀类药物免费人群的 TC 和 LDL-C 水平显著下降。在老年人群中，这种下降最为明显，而且这种趋势并没有减缓。对于 TG，在最初下降后，水平开始上升。
