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本文引用的文献

1
Long-term outcomes after gene therapy for adenosine deaminase severe combined immune deficiency.腺苷脱氨酶严重联合免疫缺陷症的基因治疗后的长期结果。
Blood. 2021 Oct 14;138(15):1304-1316. doi: 10.1182/blood.2020010260.
2
A long-term study of AAV gene therapy in dogs with hemophilia A identifies clonal expansions of transduced liver cells.一项对患有血友病 A 的狗进行的 AAV 基因治疗的长期研究发现，转导的肝细胞发生了克隆扩增。
Nat Biotechnol. 2021 Jan;39(1):47-55. doi: 10.1038/s41587-020-0741-7. Epub 2020 Nov 16.
3
Clonal tracking in gene therapy patients reveals a diversity of human hematopoietic differentiation programs.基因治疗患者的克隆追踪揭示了人类造血分化程序的多样性。
Blood. 2020 Apr 9;135(15):1219-1231. doi: 10.1182/blood.2019002350.
4
Variation in proviral content among human genomes mediated by LTR recombination.由长末端重复序列（LTR）重组介导的人类基因组中前病毒含量的变异。
Mob DNA. 2018 Dec 18;9:36. doi: 10.1186/s13100-018-0142-3. eCollection 2018.
5
VISPA2: a scalable pipeline for high-throughput identification and annotation of vector integration sites.VISPA2：一种用于高通量鉴定和注释载体整合位点的可扩展流程
BMC Bioinformatics. 2017 Nov 25;18(1):520. doi: 10.1186/s12859-017-1937-9.
6
INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes.INSPIIRED：一种用于细胞基因组中新DNA整合位点定量分析的流程
Mol Ther Methods Clin Dev. 2016 Dec 18;4:39-49. doi: 10.1016/j.omtm.2016.11.002. eCollection 2017 Mar 17.
7
INSPIIRED: Quantification and Visualization Tools for Analyzing Integration Site Distributions.INSPIIRED：用于分析整合位点分布的量化与可视化工具
Mol Ther Methods Clin Dev. 2016 Dec 18;4:17-26. doi: 10.1016/j.omtm.2016.11.003. eCollection 2017 Mar 17.
8
GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data.GENE-IS：对大规模基因治疗数据中的病毒整合事件进行高效准确的分析。
Mol Ther Nucleic Acids. 2017 Mar 17;6:133-139. doi: 10.1016/j.omtn.2016.12.001. Epub 2016 Dec 10.
9
Estimating and comparing microbial diversity in the presence of sequencing errors.在存在测序错误的情况下估计和比较微生物多样性。
PeerJ. 2016 Feb 1;4:e1634. doi: 10.7717/peerj.1634. eCollection 2016.
10
Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites.下一代测序衍生病毒载体整合位点的生物信息学克隆性分析
Hum Gene Ther Methods. 2012 Apr;23(2):111-8. doi: 10.1089/hgtb.2011.219. Epub 2012 May 4.

Challenges in estimating numbers of vectors integrated in gene-modified cells using DNA sequence information.

作者信息

Bushman Frederic D, Cantu Adrian, Everett John, Sabatino Denise, Berry Charles

机构信息

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

Mol Ther. 2021 Dec 1;29(12):3328-3331. doi: 10.1016/j.ymthe.2021.10.022. Epub 2021 Oct 29.

DOI:10.1016/j.ymthe.2021.10.022
PMID:34717818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8636165/
Abstract
摘要