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非贲门失弛缓症食管动力障碍的解析

Making Sense of Nonachalasia Esophageal Motor Disorders.

机构信息

Division of Gastroenterology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8124, St Louis, MO 63110, USA; Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville School of Medicine, 550 South Preston Street, Louisville, KY 40202, USA.

Division of Gastroenterology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8124, St Louis, MO 63110, USA.

出版信息

Gastroenterol Clin North Am. 2021 Dec;50(4):885-903. doi: 10.1016/j.gtc.2021.08.003. Epub 2021 Oct 6.

Abstract

Achalasia is the prototypical obstructive motor disorder diagnosed using HRM, but non-achalasia motor disorders are often identified in symptomatic patients. The clinical relevance of these disorders are assessed using ancillary HRM maneuvers (multiple rapid swallows, rapid drink challenge, solid swallows) that augment the standard supine HRM evaluation by challenging peristaltic function. Finding obstructive motor physiology in non-achalasia motor disorders may raise the option of invasive management akin to achalasia. Certain non-achalasia disorders, particularly hypermotility disorders, may manifest as epiphenomena seen with esophageal hypersensitivity. Symptomatic management is offered for superimposed reflux disease, psychological disorders, functional esophageal disorders, and behavioral disorders.

摘要

贲门失弛缓症是一种典型的梗阻性运动障碍,可使用高分辨率测压法(HRM)进行诊断,但在有症状的患者中,常可识别出非贲门失弛缓症性运动障碍。通过辅助 HRM 操作(多次快速吞咽、快速饮水挑战、固体吞咽)来评估这些障碍的临床相关性,这些操作通过挑战蠕动功能来增强标准仰卧位 HRM 评估。在非贲门失弛缓症性运动障碍中发现梗阻性运动生理学可能会增加类似于贲门失弛缓症的侵入性治疗选择。某些非贲门失弛缓症性疾病,特别是高动力障碍性疾病,可能表现为食管高敏性相关的伴随现象。对于叠加性反流性疾病、心理障碍、功能性食管疾病和行为障碍,可提供对症治疗。

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