Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School.
Department of Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Rheumatology (Oxford). 2022 Jul 6;61(7):2978-2986. doi: 10.1093/rheumatology/keab804.
To quantify the temporal trend of sex- and age-specific disability-adjusted life years (DALYs) for musculoskeletal (MSK) disorders by region and cause.
Data were collected from the Global Burden of Diseases Study 2019. The estimated annual percentage change (EAPC) by sex, age, region and cause was calculated to examine the temporal trend of the age-standardized DALYs rate (ASDR). The sociodemographic index (SDI) and risk exposures were also examined.
Between 1990 and 2019, the global ASDR for MSK disorders remained almost stable by sex and age group but decreased among females ages 0-14 years (EAPC = -0.27). Such age and sex patterns were nearly the same by SDI, except for high SDI regions, where ASDR increased in all subgroups except those ages 15-49 years. The trend in ASDR of MSK disorders for females and males ages 50-74 and ≥75 years increased in ∼80% of countries and territories. The greatest increase was in El Salvador for males ages 15-49 years (EAPC = 1.30), followed by Nicaragua. The association between EAPC and SDI was positive in developing regions, particularly among females ages 15-49 years, and negative in developed regions. A decreasing trend in ASDR was mainly driven by the decrease in low back pain, while the increasing trend was largely due to other MSK disorders and gout across sexes and age groups.
There are great disparities in the age- and sex-specific trends in ASDR by cause on the global, regional and national levels. More differentiated prevention and management strategies are needed for MSK disorders.
按地区和病因量化骨骼肌肉（MSK）疾病的性别和年龄特异性伤残调整生命年（DALY）的时间趋势。
数据来自 2019 年全球疾病负担研究。计算了按性别、年龄、地区和病因的估计年百分比变化（EAPC），以检查年龄标准化 DALY 率（ASDR）的时间趋势。还检查了社会人口指数（SDI）和风险暴露情况。
1990 年至 2019 年间，MSK 疾病的全球 ASDR 按性别和年龄组保持几乎稳定，但在 0-14 岁女性中下降（EAPC = -0.27）。SDI 几乎呈现相同的年龄和性别模式，除了高 SDI 地区，在这些地区，除了 15-49 岁年龄组外，所有亚组的 ASDR 都有所增加。80%以上的国家和地区，50-74 岁和≥75 岁的女性和男性的 MSK 疾病 ASDR 呈上升趋势。萨尔瓦多男性 15-49 岁年龄组的增幅最大（EAPC = 1.30），其次是尼加拉瓜。发展中地区 EAPC 与 SDI 之间呈正相关，特别是在 15-49 岁的女性中，而发达地区则呈负相关。ASDR 的下降趋势主要是由腰痛的减少引起的，而上升趋势主要归因于不同性别和年龄组的其他 MSK 疾病和痛风。
全球、区域和国家各级按病因划分的 ASDR 的性别和年龄特异性趋势存在巨大差异。需要为 MSK 疾病制定更具差异化的预防和管理策略。
