J Radiat Res. 2022 Jan 20;63(1):51-54. doi: 10.1093/jrr/rrab100.
Mycosis fungoides (MF) is a common, low-grade non-Hodgkin's lymphoma of skin-homing T lymphocytes that can be treated via skin-directed radiotherapy. Our institution has implemented total skin electron therapy (TSET) with a 4.3 m source-to-surface distance (SSD) and 6 MeV electron beams with a beam spoiler. A 35-year-old male undergoing TSET desired to avoid radiotherapy-induced hair loss and temporary infertility; therefore, leakage dose to scalp and testicles was reduced with a special radiation shield composed of stacked lead sheets. The shields for the scalp and scrotal were of 3 mm and 6 mm, respectively. To assess leakage doses, a radiophotoluminescence glass dosimeter (RPLD) was placed at every fraction. The difference dose between the measured and prescribed dose at the calibration point was 2%. The top of the head and scrotal surface exhibited 18 cGy and 10 cGy, respectively. Thus, the dose to the scrotal surface was not beyond the testicular tolerance dose of 20 cGy. Results of semen analysis two months postradiotherapy were normal. There was no hair loss during or after radiation therapy. Therefore, the RPLD is a useful in vivo dosimeter that provides technical information on radiation shielding to allow for completion of TSET without hair loss or temporary infertility.
蕈样肉芽肿(MF)是一种常见的、低级别非霍奇金淋巴瘤,属于皮肤归巢 T 淋巴细胞,可以通过皮肤定向放射疗法进行治疗。我们机构采用 4.3m 源皮距(SSD)和 6MeV 电子束的全身电子束照射疗法(TSET),同时使用束流散射片。一位 35 岁男性接受 TSET 治疗,希望避免放疗引起的脱发和暂时不育;因此,采用由多层铅片叠成的特殊放射屏蔽来减少头皮和睾丸的漏射线剂量。头皮和阴囊的屏蔽分别为 3mm 和 6mm。为了评估漏射线剂量,在每次治疗时都放置了一个放射性光致发光玻璃剂量计(RPLD)。校准点处测量剂量与规定剂量之间的差异剂量为 2%。头顶和阴囊表面的剂量分别为 18cGy 和 10cGy。因此,阴囊表面的剂量并未超过 20cGy 的睾丸耐受剂量。放射治疗两个月后的精液分析结果正常。在放射治疗过程中和之后都没有脱发。因此,RPLD 是一种有用的体内剂量计,它提供了关于放射屏蔽的技术信息,使我们能够在不脱发或不育的情况下完成 TSET。