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一种用于麻醉状态下儿科患者的全身皮肤电子线治疗(TSET)技术。

A technique for total skin electron therapy (TSET) of an anesthetized pediatric patient.

作者信息

Kron Tomas, Donahoo Grace, Lonski Peta, Wheeler Greg

机构信息

Peter MacCallum Cancer Centre, Melbourne, Australia.

Sir Peter MacCallum Cancer Department, Melbourne University, Melbourne, Australia.

出版信息

J Appl Clin Med Phys. 2018 Nov;19(6):109-116. doi: 10.1002/acm2.12457. Epub 2018 Sep 29.

Abstract

PURPOSE

Total skin electron therapy (TSET) is a technique to treat cutaneous lymphomas. While TSET is rarely required in pediatric patients, it poses particular problems for the delivery. It was the aim of the present work to develop a method to deliver TSET to young children requiring anesthetics during treatment.

METHODS

A customized cradle with a thin window base and Poly(methyl-methacrylate) (PMMA) frame was built and the patient was treated in supine position. Two times six fields of 6 MeV electrons spaced by 60° gantry angles were used without electron applicator and a field size of 36 × 36 cm . The two sets of six fields were matched at approximately 65% surface dose by rotating the patient around an axis 30 cm distance from beam central axis, effectively displacing the two sets of fields in sup/inf direction by 60 cm. Electron energy was degraded using a 12 mm PMMA block on the gantry. Focus to skin distance was maximized by displacing the patient in opposite direction of the beam resulting in a different couch position for each field.

RESULTS

A 2-yr-old patient was treated in 12 fractions of 1.5 Gy over 2.4 weeks. Dose to skin was verified daily using thermoluminescence dosimetry and/or radiochromic film. The treatment parameters were adjusted slightly based on in vivo dosimetry resulting in a dose distribution for most of the treatment volume within ±20% of the prescribed dose. Six areas were boosted using conventional electron therapy.

CONCLUSION

TSET can be delivered to pediatric patients using a customized couch top on a conventional linear accelerator.

摘要

目的

全身皮肤电子线治疗(TSET)是一种治疗皮肤淋巴瘤的技术。虽然儿科患者很少需要TSET,但该治疗方式在实施过程中存在一些特殊问题。本研究旨在开发一种方法,以便在治疗过程中为需要麻醉的幼儿提供TSET。

方法

制作了一个定制的摇篮,其底部有薄窗口,框架为聚甲基丙烯酸甲酯(PMMA)材质,患者仰卧于其上接受治疗。使用6兆电子伏的电子线,分两组,每组六个射野,机架角度间隔60°,不使用电子线限光筒,射野大小为 36×36厘米。通过让患者绕离束流中心轴30厘米的轴旋转,使两组六个射野在约65%的表面剂量处匹配,从而有效地使两组射野在头/脚方向上错开60厘米。在机架上使用12毫米厚的PMMA块对电子能量进行衰减。通过将患者向束流相反方向移动,使焦点到皮肤的距离最大化,每个射野的治疗床位置因此不同。

结果

一名2岁患者在2.4周内接受了12次分割照射,每次1.5戈瑞。每天使用热释光剂量测定法和/或放射变色胶片对皮肤剂量进行验证。根据体内剂量测定结果对治疗参数进行了微调,使得大部分治疗体积内的剂量分布在处方剂量的±20%以内。使用传统电子线治疗对六个区域进行了补充照射。

结论

在传统直线加速器上使用定制的治疗床面可为儿科患者提供TSET。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1dc5/6236825/3b669f67463e/ACM2-19-109-g001.jpg

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