Kron Tomas, Donahoo Grace, Lonski Peta, Wheeler Greg
Peter MacCallum Cancer Centre, Melbourne, Australia.
Sir Peter MacCallum Cancer Department, Melbourne University, Melbourne, Australia.
J Appl Clin Med Phys. 2018 Nov;19(6):109-116. doi: 10.1002/acm2.12457. Epub 2018 Sep 29.
Total skin electron therapy (TSET) is a technique to treat cutaneous lymphomas. While TSET is rarely required in pediatric patients, it poses particular problems for the delivery. It was the aim of the present work to develop a method to deliver TSET to young children requiring anesthetics during treatment.
A customized cradle with a thin window base and Poly(methyl-methacrylate) (PMMA) frame was built and the patient was treated in supine position. Two times six fields of 6 MeV electrons spaced by 60° gantry angles were used without electron applicator and a field size of 36 × 36 cm . The two sets of six fields were matched at approximately 65% surface dose by rotating the patient around an axis 30 cm distance from beam central axis, effectively displacing the two sets of fields in sup/inf direction by 60 cm. Electron energy was degraded using a 12 mm PMMA block on the gantry. Focus to skin distance was maximized by displacing the patient in opposite direction of the beam resulting in a different couch position for each field.
A 2-yr-old patient was treated in 12 fractions of 1.5 Gy over 2.4 weeks. Dose to skin was verified daily using thermoluminescence dosimetry and/or radiochromic film. The treatment parameters were adjusted slightly based on in vivo dosimetry resulting in a dose distribution for most of the treatment volume within ±20% of the prescribed dose. Six areas were boosted using conventional electron therapy.
TSET can be delivered to pediatric patients using a customized couch top on a conventional linear accelerator.
全身皮肤电子线治疗(TSET)是一种治疗皮肤淋巴瘤的技术。虽然儿科患者很少需要TSET,但该治疗方式在实施过程中存在一些特殊问题。本研究旨在开发一种方法,以便在治疗过程中为需要麻醉的幼儿提供TSET。
制作了一个定制的摇篮,其底部有薄窗口,框架为聚甲基丙烯酸甲酯(PMMA)材质,患者仰卧于其上接受治疗。使用6兆电子伏的电子线,分两组,每组六个射野,机架角度间隔60°,不使用电子线限光筒,射野大小为 36×36厘米。通过让患者绕离束流中心轴30厘米的轴旋转,使两组六个射野在约65%的表面剂量处匹配,从而有效地使两组射野在头/脚方向上错开60厘米。在机架上使用12毫米厚的PMMA块对电子能量进行衰减。通过将患者向束流相反方向移动,使焦点到皮肤的距离最大化,每个射野的治疗床位置因此不同。
一名2岁患者在2.4周内接受了12次分割照射,每次1.5戈瑞。每天使用热释光剂量测定法和/或放射变色胶片对皮肤剂量进行验证。根据体内剂量测定结果对治疗参数进行了微调,使得大部分治疗体积内的剂量分布在处方剂量的±20%以内。使用传统电子线治疗对六个区域进行了补充照射。
在传统直线加速器上使用定制的治疗床面可为儿科患者提供TSET。