Antolak J A, Cundiff J H, Ha C S
Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Int J Radiat Oncol Biol Phys. 1998 Jan 1;40(1):101-8. doi: 10.1016/s0360-3016(97)00585-3.
The purpose of this report is to discuss the utilization of thermoluminescent dosimetry (TLD) in total skin electron beam (TSEB) radiotherapy to: (a) compare patient dose distributions for similar techniques on different machines, (b) confirm beam calibration and monitor unit calculations, (c) provide data for making clinical decisions, and (d) study reasons for variations in individual dose readings.
We report dosimetric results for 72 cases of mycosis fungoides, using similar irradiation techniques on two different linear accelerators. All patients were treated using a modified Stanford 6-field technique. In vivo TLD was done on all patients, and the data for all patients treated on both machines was collected into a database for analysis. Means and standard deviations (SDs) were computed for all locations. Scatter plots of doses vs. height, weight, and obesity index were generated, and correlation coefficients with these variables were computed.
The TLD results show that our current TSEB implementation is dosimetrically equivalent to the previous implementation, and that our beam calibration technique and monitor unit calculation is accurate. Correlations with obesity index were significant at several sites. Individual TLD results allow us to customize the boost treatment for each patient, in addition to revealing patient positioning problems and/or systematic variations in dose caused by patient variability. The data agree well with previously published TLD results for similar TSEB techniques.
TLD is an important part of the treatment planning and quality assurance programs for TSEB, and routine use of TLD measurements for TSEB is recommended.
本报告旨在探讨热释光剂量测定法(TLD)在全身皮肤电子束(TSEB)放射治疗中的应用,以:(a)比较不同机器上类似技术的患者剂量分布;(b)确认射束校准和监测单元计算;(c)提供用于临床决策的数据;(d)研究个体剂量读数变化的原因。
我们报告了72例蕈样肉芽肿患者的剂量测定结果,在两台不同的直线加速器上使用了类似的照射技术。所有患者均采用改良的斯坦福6野技术进行治疗。对所有患者进行了体内TLD测量,并将两台机器上治疗的所有患者的数据收集到一个数据库中进行分析。计算了所有位置的均值和标准差(SD)。生成了剂量与身高、体重和肥胖指数的散点图,并计算了与这些变量的相关系数。
TLD结果表明,我们目前的TSEB实施在剂量测定上与之前的实施相当,并且我们的射束校准技术和监测单元计算是准确的。在几个部位,与肥胖指数的相关性显著。个体TLD结果不仅能让我们为每位患者定制强化治疗,还能揭示患者定位问题和/或因患者个体差异导致的剂量系统变化。这些数据与之前发表的类似TSEB技术的TLD结果非常吻合。
TLD是TSEB治疗计划和质量保证计划的重要组成部分,建议对TSEB常规使用TLD测量。