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口服不同浓度的氧化银纳米颗粒对高尿酸血症小鼠的体内影响。

In Vivo Effects of Orally Administered Different Concentrations of Silver Oxide Nanoparticles in Hyperuricemic Mice.

机构信息

Shifa College of Medical Technology, Shifa Tameer-E-Millat University, Islamabad, Pakistan.

Shifa International Hospitals, Ltd 'Gate No. 1' 4 Pitras Bukhari Rd, H 8/4 H-8, Islamabad, Islamabad Capital Territory, Pakistan.

出版信息

Biol Trace Elem Res. 2022 Aug;200(8):3677-3687. doi: 10.1007/s12011-021-02960-3. Epub 2021 Oct 31.

DOI:10.1007/s12011-021-02960-3
PMID:34718960
Abstract

Silver oxide nanoparticles (AgO-NPs) antioxidant, anti-cancer, anti-microbial, and tissue repair properties. Gouty arthritis is the inflammation of tissues and joints caused by the deposition of monosodium urate crystals. In this experiment, we investigated the anti-hyperuricemic effectiveness of different concentrations of AgO-NPs in mice. The present study aimed to investigate the effect of administration of AgO-NPs in monosodium urate (MSU)-induced gouty mice for the very first time. Monosodium urate (MSU) crystals were administered intraperitoneal for gout induction, followed by 5, 10, and 20 µg/mL doses of AgO-NPs for 2 weeks. The positive control was provided with the commercially available drug allopurinol to compare the effects of AgO-NPs and allopurinol. The main purpose of the study was to investigate the effectiveness of the nanoparticles in comparison with commercially available drugs. AgO-NPs have been shown to improve the condition of gouty arthritis by reducing significantly (P ˂ 0.001) increased levels of ALT, AST, and total bilirubin. The total protein estimation results showed significant improvement at concentration of 20 µg/mL of AgO-NPs. The lipid profile results showed that high concentration (20 µg/mL) of AgO-NPs decrease the lipid content significantly as compared to control. It was concluded from this study that the antioxidant, anti-inflammatory, and antilipidemic properties of AgO-NPs may improve the hyperuricemic condition in gouty arthritis mice.

摘要

氧化银纳米颗粒 (AgO-NPs) 具有抗氧化、抗癌、抗菌和组织修复特性。痛风性关节炎是由单钠尿酸盐晶体沉积引起的组织和关节炎症。在这项实验中，我们研究了不同浓度的 AgO-NPs 在小鼠中的抗高尿酸血症效果。本研究旨在首次研究 AgO-NPs 在尿酸单钠 (MSU) 诱导的痛风性小鼠中的作用。通过腹腔内给予 MSU 晶体诱导痛风，然后给予 5、10 和 20μg/mL 的 AgO-NPs 剂量，持续 2 周。阳性对照用市售药物别嘌醇提供，以比较 AgO-NPs 和别嘌醇的效果。研究的主要目的是研究与市售药物相比，纳米颗粒的有效性。AgO-NPs 通过显著降低（P ˂ 0.001）ALT、AST 和总胆红素水平，改善痛风性关节炎的状况。总蛋白估计结果表明，AgO-NPs 的浓度为 20μg/mL 时，情况有明显改善。脂质谱结果表明，与对照组相比，高浓度（20μg/mL）的 AgO-NPs 显著降低了脂质含量。综上所述，AgO-NPs 的抗氧化、抗炎和抗脂特性可能改善痛风性关节炎小鼠的高尿酸血症状况。

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J Trace Elem Med Biol. 2019 Dec;56:169-177. doi: 10.1016/j.jtemb.2019.08.012. Epub 2019 Aug 24.
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