Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, 11 Arany Janos Street, RO 400028 Cluj-Napoca, Romania.
National Institute for Research and Development of Isotopic and Molecular Technologies, 65-103 Donath Street, RO 400293 Cluj-Napoca, Romania.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:720-727. doi: 10.1016/j.msec.2017.05.122. Epub 2017 May 17.
A green, rapid and cost effective method for the bio-synthesis of silver nanoparticles (AgNPs), using polyphenols present in European cranberry bush fruit extracts was developed. The obtained AgNPs were characterized by ultra-violet visible spectroscopy (UV-VIS), Fourier transform - infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray diffraction patterns (XRD). The average size of the spherical AgNPs was found to be 25nm. The anti-inflammatory effect of the biomaterials was investigated, both in vitro (on HaCaT cell line, exposed to UVB radiation) and in vivo (on acute inflammation model in Wistar rats). Our results support the conclusion that the photosynthesized silver nanoparticles present a potent anti-inflammatory activity and could be successfully used as therapeutic tools for treatment of inflammation.
开发了一种使用欧洲越橘果实提取物中的多酚绿色、快速且具有成本效益的方法来生物合成银纳米粒子（AgNPs）。通过紫外可见光谱（UV-VIS）、傅里叶变换-红外光谱（FT-IR）、透射电子显微镜（TEM）和 X 射线衍射图谱（XRD）对所得到的 AgNPs 进行了表征。发现球形 AgNPs 的平均尺寸为 25nm。研究了生物材料的抗炎作用，包括体外（HaCaT 细胞系，暴露于 UVB 辐射下）和体内（Wistar 大鼠急性炎症模型）。我们的结果支持这样的结论，即光合作用合成的银纳米粒子具有很强的抗炎活性，可成功用作治疗炎症的治疗工具。
