Department of Ultrasound, First Affiliated Hospital, Shantou Unviersity Medical College, Shantou, Guangdong, China.
Shantou University Medical College, Shantou, Guangdong, China.
Clin Hemorheol Microcirc. 2022;80(3):317-325. doi: 10.3233/CH-211258.
Tumor angiogenesis plays a critical role in the growth and metastasis of breast cancer. Evaluating the added value of vascular features to Breast Imaging Reporting and Data System (BI-RADS) in differentiating malignant masses from benign ones is essential. Micro-flow Imaging (MFI) is a promising noninvasive diagnostic method for the microvessels in breast tumors, but its precise value is still uncertain.
Understanding whether malignant tumor vascular characteristics by MFI are associated with breast cancer and whether the diagnostic efficiency varies by age.
B-mode ultrasound and MFI were performed for 153 solid breast lesions. The vessels images by MFI were reviewed and assessed by two investigators, respectively. Then the diagnostic efficacy of different vascular features combined with BI-RADS was evaluated in different age groups.
The mean size of lesions is 19.4 (range 18-78) mm. There were 94 breast masses in benign, while 59 breast masses in malignant by pathology. III Adler classification, penetrating vessels, and complex flow pattern showed a positive association with a high risk of malignant breast lesions (p < 0.05). BI-RADS combined with vessel characteristics show better improvement of diagnostic performance of breast lesions in the elderly group than in the young group.
Vascular features by MFI contribute to malignant breast masses' diagnosis, and the association might be modified by age.
肿瘤血管生成在乳腺癌的生长和转移中起着关键作用。评估血管特征对乳腺影像报告和数据系统（BI-RADS）在区分良恶性肿块中的附加价值至关重要。微流成像（MFI）是一种有前途的用于检测乳腺肿瘤中小血管的非侵入性诊断方法，但它的确切价值仍不确定。
了解 MFI 检测到的恶性肿瘤血管特征是否与乳腺癌相关，以及诊断效率是否随年龄而变化。
对 153 个实性乳腺病变进行了 B 型超声和 MFI 检查。由两位研究者分别对 MFI 血管图像进行回顾性评估。然后，评估不同年龄组中不同血管特征与 BI-RADS 联合应用的诊断效能。
病变的平均大小为 19.4（范围 18-78）mm。病理检查显示，94 个乳腺肿块为良性，59 个乳腺肿块为恶性。III 级 Adler 分类、穿透性血管和复杂血流模式与恶性乳腺病变的高风险呈正相关（p<0.05）。BI-RADS 联合血管特征显示，在老年组中，对乳腺病变的诊断性能改善优于年轻组。
MFI 检测到的血管特征有助于恶性乳腺肿块的诊断，这种相关性可能受年龄的影响。
