Graduate School of Comprehensive Human Sciences, University of Tsukuba.
Reserch Fellow in Japan Society for Promotion Science.
J Nutr Sci Vitaminol (Tokyo). 2021;67(5):317-322. doi: 10.3177/jnsv.67.317.
Nutritional supplements are sometimes important for athletes to improve their sports performance and maintain their condition. Maslinic acid (MA) is a type of compound with a pentacyclic triterpene structure extracted from olives, and has a strong anti-inflammatory effect and improves metabolic function. This study aimed to investigate the effects of MA on muscle hypertrophy by functional overload using an animal model. Mice plantaris muscles were overloaded by synergist ablation surgery with/without MA and they were sampled at 4, 7, and 14 d after the operation. We demonstrated that MA significantly increased plantaris' cross-sectional area and activated the mechanistic target of rapamycin (mTOR) signaling compared with the non-supplemented group (main effect of MA, p<0.05). In addition, MA also significantly reduced catabolic proteins compared with the non-supplemented group. MA supplementation increased muscle fiber size and promoted muscle hypertrophy via mTOR signaling. Our results indicate that MA supplementation may be useful for promoting hypertrophy of skeletal muscle.
营养补充剂有时对运动员很重要，可以提高他们的运动表现和保持身体状态。齐墩果酸（MA）是一种从橄榄中提取的五环三萜化合物，具有很强的抗炎作用和改善代谢功能。本研究旨在通过动物模型研究 MA 通过功能超负荷对肌肉肥大的影响。通过协同肌切除手术使小鼠比目鱼肌超负荷，手术后 4、7 和 14 天取样。结果表明，与未补充组相比，MA 显著增加了比目鱼肌的横截面积并激活了雷帕霉素（mTOR）信号（MA 的主要作用，p<0.05）。此外，MA 还显著降低了与未补充组相比的分解代谢蛋白。MA 补充剂通过 mTOR 信号增加肌肉纤维大小并促进肌肉肥大。我们的结果表明，MA 补充剂可能有助于促进骨骼肌肥大。
