Tsukuba Life Science Innovation Program (T-LSI), University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan.
Central Research Laboratory Innovation Center, Nippn Corporation, 5-1-3 Midorigaoka, Atsugi 243-0041, Japan.
Nutrients. 2021 Aug 25;13(9):2950. doi: 10.3390/nu13092950.
Maslinic acid (MA) is a pentacyclic triterpene abundant in olive peels. MA reportedly increases skeletal muscle mass and strength in older adults; however, the underlying mechanism is unknown. This study aimed to investigate the effects of MA on denervated muscle atrophy and strength and to explore the underlying molecular mechanism. Mice were fed either a control diet or a 0.27% MA diet. One week after intervention, the sciatic nerves of both legs were cut to induce muscle atrophy. Mice were examined 14 days after denervation. MA prevented the denervation-induced reduction in gastrocnemius muscle mass and skeletal muscle strength. Microarray gene expression profiling in gastrocnemius muscle demonstrated several potential mechanisms for muscle maintenance. Gene set enrichment analysis (GSEA) revealed different enriched biological processes, such as myogenesis, PI3/AKT/mTOR signaling, TNFα signaling via NF-κB, and TGF-β signaling in MA-treated mice. In addition, qPCR data showed that MA induced expression and suppressed the expressions of and . Altogether, our results suggest the potential of MA as a new therapeutic and preventive dietary ingredient for muscular atrophy and strength.
马尿酸（MA）是一种在橄榄皮中含量丰富的五环三萜。有报道称，MA 可以增加老年人的骨骼肌质量和力量；然而，其潜在机制尚不清楚。本研究旨在探讨 MA 对失神经肌肉萎缩和力量的影响，并探索其潜在的分子机制。小鼠分别喂食对照饮食或 0.27%MA 饮食。干预 1 周后，切断双侧坐骨神经以诱导肌肉萎缩。在去神经后 14 天检查小鼠。MA 可防止失神经引起的比目鱼肌质量和骨骼肌力量下降。比目鱼肌的微阵列基因表达谱分析显示了几种维持肌肉的潜在机制。基因集富集分析（GSEA）显示，MA 处理的小鼠中存在不同的富集生物学过程，如肌生成、PI3/AKT/mTOR 信号、通过 NF-κB 的 TNFα 信号和 TGF-β 信号。此外，qPCR 数据显示 MA 诱导了 表达，并抑制了 和 的表达。总之，我们的研究结果表明 MA 作为一种新的治疗和预防肌肉萎缩和力量的膳食成分具有潜力。
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