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本文引用的文献

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Evaluation of renal drug dosing adjustment in chronic kidney disease patients at two university hospitals in Lebanon.黎巴嫩两家大学医院慢性肾病患者肾药物剂量调整的评估。
Pharm Pract (Granada). 2019 Jan-Mar;17(1):1304. doi: 10.18549/PharmPract.2019.1.1304. Epub 2019 Feb 27.
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Medication Reconciliation at Discharge from Hospital: A Systematic Review of the Quantitative Literature.医院出院时的用药核对:对定量文献的系统评价
Pharmacy (Basel). 2015 Jun 23;3(2):53-71. doi: 10.3390/pharmacy3020053.
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Renal Drug Dosage Adjustment According to Estimated Creatinine Clearance in Hospitalized Patients With Heart Failure.根据估算的肌酐清除率对心力衰竭住院患者进行肾脏药物剂量调整
Am J Ther. 2016 Jul-Aug;23(4):e1004-8. doi: 10.1097/01.mjt.0000434042.62372.49.
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Impact of a renal drug dosing service on dose adjustment in hospitalized patients with chronic kidney disease.肾脏药物剂量调整服务对慢性肾脏病住院患者剂量调整的影响。
Ann Pharmacother. 2009 Oct;43(10):1598-605. doi: 10.1345/aph.1M187. Epub 2009 Sep 23.
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Chronic kidney disease and its complications.慢性肾脏病及其并发症。
Prim Care. 2008 Jun;35(2):329-44, vii. doi: 10.1016/j.pop.2008.01.008.
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Overdose rate of drugs requiring renal dose adjustment: data analysis of 4 years prescriptions at a tertiary teaching hospital.需要调整肾脏剂量的药物的过量使用率:一家三级教学医院4年处方的数据分析
J Gen Intern Med. 2008 Apr;23(4):423-8. doi: 10.1007/s11606-007-0336-8.
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Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.慢性肾脏病与死亡、心血管事件及住院风险
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8
Clinical pharmacy services, hospital pharmacy staffing, and medication errors in United States hospitals.美国医院的临床药学服务、医院药房人员配备及用药错误
Pharmacotherapy. 2002 Feb;22(2):134-47. doi: 10.1592/phco.22.3.134.33551.
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Interrelationships among mortality rates, drug costs, total cost of care, and length of stay in United States hospitals: summary and recommendations for clinical pharmacy services and staffing.美国医院死亡率、药品成本、护理总成本及住院时间之间的相互关系:临床药学服务与人员配置的总结及建议
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Prediction of creatinine clearance from serum creatinine.根据血清肌酐预测肌酐清除率。
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药剂师肾剂量调整评估及药剂师服务未来评估规划

Evaluation of Pharmacist Renal Dose Adjustments and Planning for Future Evaluations of Pharmacist Services.

作者信息

Bassett Elizabeth, Frantzen Leah, Zabel Katie

机构信息

HealthEast St. Joseph's Hospital, St. Paul, MN, USA.

出版信息

Hosp Pharm. 2021 Oct;56(5):416-423. doi: 10.1177/0018578720918363. Epub 2020 May 4.

DOI:10.1177/0018578720918363
PMID:34720140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8554591/
Abstract

Clinical pharmacy services are known to improve patient outcomes. Pharmacists contribute to patient care in the acute care setting in multiple ways, including providing advice and information to patients and the health care team, performing medication histories to prevent waste and support medication adherence, analyzing the cost-effectiveness of medications, and ensuring patient safety through patient monitoring and medication review. Specific clinical pharmacist services include managing intravenous to oral medication adjustments, renal dose adjustments, and performing pharmacokinetic dosing of medications, among others. Many of these clinical services are performed daily but are not evaluated for clinical quality or compliance with policies. Evaluating these clinical services may provide a multitude of benefits to pharmacy departments, health systems, and patients. The purpose of this study was to evaluate pharmacist use and percent compliance of a renal dose adjustment policy upon initial order verification and discharge. This was completed through retrospective chart review to determine if dose adjustments were made appropriately and descriptive statistics were used to establish pharmacist compliance. Those orders that were inappropriately adjusted were analyzed for trends that could lead to possible policy improvements or pharmacist education opportunities. The completed evaluation also led to the development of an evaluation system that can be utilized to routinely assess clinical pharmacist services. The results of this study are being used to develop and support future clinical service evaluations, inspire process improvements, and improve patient outcomes and pharmacist accountability.

摘要

临床药学服务有助于改善患者预后。药剂师通过多种方式在急性护理环境中为患者护理做出贡献,包括向患者和医疗团队提供建议和信息、进行用药史调查以防止浪费并支持患者坚持用药、分析药物的成本效益,以及通过患者监测和药物审查确保患者安全。具体的临床药剂师服务包括管理静脉给药到口服给药的调整、肾剂量调整以及进行药物的药代动力学给药等。许多这些临床服务每天都在进行,但未对临床质量或政策合规性进行评估。评估这些临床服务可能会给药房、医疗系统和患者带来诸多益处。本研究的目的是评估药剂师在初始医嘱核实和出院时对肾剂量调整政策的使用情况和合规百分比。这是通过回顾性病历审查来完成的,以确定剂量调整是否恰当,并使用描述性统计来确定药剂师的合规情况。对那些调整不当的医嘱进行分析,以找出可能导致政策改进或药剂师教育机会的趋势。完成的评估还促成了一个可用于定期评估临床药剂师服务的评估系统的开发。本研究的结果正被用于开展和支持未来的临床服务评估、推动流程改进,并改善患者预后以及药剂师的问责制。