Chindo Ben A, Howes Melanie-Jayne R, Abuhamdah Sawsan, Yakubu Musa I, Ayuba Godwin I, Battison Alex, Chazot Paul L
Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Kaduna State University, Kaduna, Nigeria.
Royal Botanic Gardens Kew, Richmond, United Kingdom.
Front Pharmacol. 2021 Oct 14;12:760674. doi: 10.3389/fphar.2021.760674. eCollection 2021.
L. is used in traditional European and Iranian folk medicines to treat a plethora of neurological diseases including epilepsy. We utilized the and models of epilepsy to probe the anticonvulsant potentials of essential oil from (MO) to gain insight into the scientific basis for its applications in traditional medicine for the management of convulsive disorders. MO was evaluated for effects on maximal electroshock (MES) and pentylenetetrazole (PTZ) -induced seizures in mice, on 4-aminopyridine (4-AP)-brain slice model of epilepsy and sustained repetitive firing of current clamped neurons; and its ameliorative effects were examined on seizure severity, anxiety, depression, cognitive dysfunction, oxidative stress and neuronal cell loss in PTZ-kindled rats. MO reversibly blocked spontaneous ictal-like discharges in the 4-AP-brain slice model of epilepsy and secondary spikes from sustained repetitive firing, suggesting anticonvulsant effects and voltage-gated sodium channel blockade. MO protected mice from PTZ- and MES-induced seizures and mortality, and ameliorated seizure severity, fear-avoidance, depressive-like behavior, cognitive deficits, oxidative stress and neuronal cell loss in PTZ-kindled rats. The findings warrant further study for the potential use of MO and/or its constituent(s) as adjunctive therapy for epileptic patients.
L. 在传统欧洲和伊朗民间药物中用于治疗包括癫痫在内的多种神经系统疾病。我们利用癫痫的[具体模型1]和[具体模型2]来探究[植物名称]精油（MO）的抗惊厥潜力，以深入了解其在传统医学中用于治疗惊厥性疾病的科学依据。对MO在小鼠最大电休克（MES）和戊四氮（PTZ）诱导的癫痫发作、癫痫的4-氨基吡啶（4-AP）脑片模型以及电流钳制神经元的持续重复放电方面的作用进行了评估；并在PTZ点燃的大鼠中研究了其对癫痫发作严重程度、焦虑、抑郁、认知功能障碍、氧化应激和神经元细胞损失的改善作用。MO在癫痫的4-AP脑片模型中可逆地阻断了自发的癫痫样放电以及持续重复放电产生的继发性尖峰，提示其具有抗惊厥作用和对电压门控钠通道的阻断作用。MO保护小鼠免受PTZ和MES诱导的癫痫发作及死亡，并改善了PTZ点燃大鼠的癫痫发作严重程度、恐惧回避、抑郁样行为、认知缺陷、氧化应激和神经元细胞损失。这些发现为进一步研究MO和/或其成分作为癫痫患者辅助治疗的潜在用途提供了依据。
