Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine.
Neuro-Pal Center, Birzeit, Palestine.
Neurochem Res. 2024 Feb;49(2):258-289. doi: 10.1007/s11064-023-04032-5. Epub 2023 Sep 28.
Numerous studies have demonstrated essential oils' diverse chemical compositions and pharmacological properties encompassing antinociceptive, anxiolytic-like, and anticonvulsant activities, among other notable effects. The utilization of essential oils, whether inhaled, orally ingested, or applied topically, has commonly been employed as adjunctive therapy for individuals experiencing anxiety, insomnia, convulsions, pain, and cognitive impairment. The utilization of synthetic medications in the treatment of various disorders and symptoms is associated with a wide array of negative consequences. Consequently, numerous research groups across the globe have been prompted to explore the efficacy of natural alternatives such as essential oils. This review provides a comprehensive overview of the existing literature on the pharmacological properties of essential oils and their derived compounds and the underlying mechanisms responsible for these observed effects. The primary emphasis is on essential oils and their constituents, specifically targeting the nervous system and exhibiting significant potential in treating neurodegenerative disorders. The current state of research in this field is characterized by its preliminary nature, highlighting the necessity for a more comprehensive overlook of the therapeutic advantages of essential oils and their components. Integrating essential oils into conventional therapies can enhance the effectiveness of comprehensive treatment regimens for neurodegenerative diseases, offering a more holistic approach to addressing the multifaceted nature of these conditions.
许多研究已经证明了精油的多样化化学组成和药理学特性，包括镇痛、抗焦虑样和抗惊厥活性等显著作用。精油的使用，无论是吸入、口服还是局部应用，通常被用作焦虑、失眠、惊厥、疼痛和认知障碍患者的辅助治疗。在治疗各种疾病和症状时使用合成药物会带来一系列负面影响。因此，全球许多研究小组都被促使去探索天然替代品，如精油的功效。这篇综述提供了精油及其衍生化合物的药理学特性以及这些观察到的作用的潜在机制的现有文献的全面概述。重点是精油及其成分，特别是针对神经系统，并在治疗神经退行性疾病方面显示出巨大的潜力。该领域研究的现状具有初步性，突出表明需要更全面地了解精油及其成分的治疗优势。将精油纳入常规疗法可以增强神经退行性疾病综合治疗方案的效果，为解决这些疾病的多方面性质提供更全面的方法。
