Barnard R J, Hall J A, Chaudhari A, Miller J E, Kirschenbaum M A
Prostaglandins Leukot Med. 1987 Mar;26(3):241-52. doi: 10.1016/0262-1746(87)90034-5.
The purpose of this study was to test the effects of a low-fat, low-cholesterol diet on serum lipids, platelet aggregation, thromboxane formation and blood pressure. Fifteen hyperlipidemic males with normal blood pressure were treated for 2 weeks. Resting supine blood pressure, total serum cholesterol, HDL-cholesterol, the ratio of total cholesterol/HDL-cholesterol and triglycerides all were significantly reduced. The maximum aggregation and velocity of aggregation for isolated platelets stimulated with either ADP or collagen was significantly reduced. Thromboxane formation during 5 min of platelet aggregation with collagen or ADP was also significantly reduced. These results have important implications for hypertension and atherosclerotic cardiovascular disease.
本研究的目的是测试低脂、低胆固醇饮食对血脂、血小板聚集、血栓素形成和血压的影响。15名血压正常的高脂血症男性接受了为期2周的治疗。静息仰卧位血压、总血清胆固醇、高密度脂蛋白胆固醇、总胆固醇/高密度脂蛋白胆固醇比值和甘油三酯均显著降低。用二磷酸腺苷（ADP）或胶原刺激分离的血小板时，其最大聚集率和聚集速度均显著降低。用胶原或ADP诱导血小板聚集5分钟期间的血栓素形成也显著减少。这些结果对高血压和动脉粥样硬化性心血管疾病具有重要意义。
