Stanko R T, Reynolds H R, Hoyson R, Janosky J E, Wolf R
Department of Medicine, Montefiore University Hospital, Pittsburgh, PA 15213-2582.
Am J Clin Nutr. 1994 Feb;59(2):423-7. doi: 10.1093/ajcn/59.2.423.
The effects of the three-carbon compound pyruvate on plasma lipid concentrations and body composition were evaluated in hyperlipidemic patients consuming a low-cholesterol (165-180 mg), low-fat (22-24% of energy; 18-20% of energy as saturated fatty acid) diet (0.091-0.099 MJ.kg body wt-1 x d-1). After consuming the above diet for 4 wk, during which time plasma lipid concentrations decreased, 34 subjects were randomly assigned to receive either 22-44 g pyruvate (n = 17) or 18-35 g polyglucose (placebo, Polycose, n = 17), iso-energetically substituted for a portion of carbohydrate energy for 6 wk. Despite greater weight and fat losses with pyruvate (P < 0.05), plasma concentrations of cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride were not different between the two groups of subjects. We conclude that subsequent to diet-induced reduction in plasma lipid concentrations, pyruvate supplementation of a low-cholesterol, low-fat diet providing 6.7-7.6 MJ/d for 6 wk has no effect on plasma lipid concentrations but enhances body weight and fat losses.
在食用低胆固醇（165 - 180毫克）、低脂肪（占能量的22 - 24%；饱和脂肪酸占能量的18 - 20%）饮食（0.091 - 0.099兆焦·千克体重⁻¹·天⁻¹）的高脂血症患者中，评估了三碳化合物丙酮酸对血浆脂质浓度和身体成分的影响。在食用上述饮食4周后（在此期间血浆脂质浓度下降），34名受试者被随机分配接受22 - 44克丙酮酸（n = 17）或18 - 35克聚葡萄糖（安慰剂，Polycose，n = 17），以等能量方式替代一部分碳水化合物能量，持续6周。尽管丙酮酸组的体重和脂肪减少更多（P < 0.05），但两组受试者的血浆胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯浓度并无差异。我们得出结论，在饮食引起血浆脂质浓度降低之后，在为期6周的时间里，每天提供6.7 - 7.6兆焦能量的低胆固醇、低脂肪饮食中补充丙酮酸，对血浆脂质浓度没有影响，但会增加体重减轻和脂肪减少。
