Bagger M, Andersen O, Nielsen J B, Ryttig K R
Department of Environmental Medicine, Odense University, Denmark.
Br J Nutr. 1996 Mar;75(3):483-93. doi: 10.1079/bjn19960149.
The effects of dietary fat and dietary fibres on blood pressure, serum lipids and platelet aggregation in spontaneously hypertensive and Wistar-Kyoto rats have been investigated. The systolic and diastolic blood pressure values were increased with increasing amounts of dietary fat and normalized by dietary fibre supplementation. The greatest reduction in blood pressure was obtained by a combination of reduced dietary fat and supplementary dietary fibre. Addition of dietary fibre when the amount of dietary fat was high or reduction of dietary fat when the amount of dietary fibre was low gave a smaller effect. In both rat strains the decreases in systolic and diastolic blood pressure values after reducing dietary fat and/or increasing dietary fibre were about 10-15 mmHg. Serum total cholesterol and serum HDL-cholesterol concentrations were reduced by reduction of dietary fat or a combination of dietary fat reduction and dietary fibre addition. A combination of dietary fat reduction and dietary fibre addition was the most effective dietary change for reducing serum triacylglycerol concentration and platelet aggregation. The present study demonstrates that in this experimental model it is possible to reduce risk indicators of coronary heart disease significantly by changing dietary habits.
已经研究了膳食脂肪和膳食纤维对自发性高血压大鼠和Wistar-Kyoto大鼠的血压、血脂及血小板聚集的影响。收缩压和舒张压值随膳食脂肪量的增加而升高，而通过补充膳食纤维可使其恢复正常。通过减少膳食脂肪和补充膳食纤维相结合的方式，血压降低幅度最大。当膳食脂肪量高时添加膳食纤维或当膳食纤维量低时减少膳食脂肪，效果较小。在两种大鼠品系中，减少膳食脂肪和/或增加膳食纤维后，收缩压和舒张压值的降低幅度约为10 - 15 mmHg。通过减少膳食脂肪或同时减少膳食脂肪并添加膳食纤维，血清总胆固醇和血清高密度脂蛋白胆固醇浓度降低。减少膳食脂肪并添加膳食纤维相结合是降低血清三酰甘油浓度和血小板聚集最有效的饮食改变方式。本研究表明，在该实验模型中，通过改变饮食习惯可显著降低冠心病的风险指标。
