Ghavipanje Navid, Fathi Nasri Mohammad Hasan, Farhangfar Seyyed Homayoun, Ghiasi Seyyed Ehsan, Vargas-Bello-Pérez Einar
Department of Animal Science, Faculty of Agriculture, University of Birjand, Birjand, Iran.
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.
Front Vet Sci. 2021 Oct 14;8:743455. doi: 10.3389/fvets.2021.743455. eCollection 2021.
As in dairy cattle, goats during the transition period face risk factors, in particular negative energy balance (NEB), inflammation, and impairment of the antioxidant response. The current study determined the effects of pre- and post-partum berberine (BBR) supplementation on antioxidant status and inflammation response during the transition period in dairy goats. Twenty-four primiparous Saanen goats were randomly divided into four groups: control (CON, without BBR) and supplemented with 1 g/day BBR (BBR1), 2 g/day BBR (BBR2), or 4 g/day BBR (BBR4). The blood samples were collected weekly from 21 days pre-partum to 21 days post-partum. Compared with CON, supplementation with either BBR2 or BBR4 decreased ( ≤ 0.05) the levels of plasma non-esterified fatty acids (NEFA) at kidding and thereafter an increased ( ≤ 0.05) the plasma levels of glucose and insulin. Following BBR ingestion, blood antioxidant status elevated throughout the transition period, so that total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase activity were increased ( ≤ 0.05) and plasma malondialdehyde (MDA) was decreased ( ≤ 0.05). Likewise, paraoxonase (PON) was reduced ( ≤ 0.05) in goats fed BBR2 and BBR4. The levels of haptoglobin, ceruloplasmin, and bilirubin were reduced ( ≤ 0.05) by BBR2 and BBR4 immediately before kidding and thereafter. The results demonstrated that supplementation of either 2 or 4 g/day BBR enhanced antioxidant capacity and immune function of transition goats and improved post-partum performance showing its beneficial effect to mitigate oxidative stress and inflammation during the transition period in dairy goats.
与奶牛一样，处于围产期的山羊面临多种风险因素，尤其是负能量平衡（NEB）、炎症和抗氧化反应受损。本研究确定了产前和产后补充黄连素（BBR）对奶山羊围产期抗氧化状态和炎症反应的影响。将24只初产萨能山羊随机分为四组：对照组（CON，不补充BBR）以及分别补充1克/天BBR（BBR1）、2克/天BBR（BBR2）或4克/天BBR（BBR4）的组。从产前21天到产后21天每周采集血样。与对照组相比，补充BBR2或BBR4可降低（≤0.05）产羔时血浆非酯化脂肪酸（NEFA）水平，此后可提高（≤0.05）血浆葡萄糖和胰岛素水平。摄入BBR后，整个围产期血液抗氧化状态升高，总抗氧化能力（TAC）、谷胱甘肽过氧化物酶（GSH-Px）、超氧化物歧化酶（SOD）和过氧化氢酶活性增加（≤0.05），血浆丙二醛（MDA）降低（≤0.05）。同样，饲喂BBR2和BBR4的山羊对氧磷酶（PON）降低（≤0.05）。BBR2和BBR4在产羔前及之后可降低（≤0.05）触珠蛋白、铜蓝蛋白和胆红素水平。结果表明，每天补充2克或4克BBR可增强围产山羊的抗氧化能力和免疫功能，并改善产后性能，显示出其在减轻奶山羊围产期氧化应激和炎症方面的有益作用。
