Roman Adina, Moldovan Septimiu, Santini Ario, Stoian Mircea, Dobru Daniela
Mures County Hospital, Targu Mures, Romania.
George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Targu Mures, Romania.
J Crit Care Med (Targu Mures). 2021 Aug 5;7(3):211-216. doi: 10.2478/jccm-2021-0021. eCollection 2021 Jul.
The World Health Organization (WHO) identified a novel coronavirus, originating in Wuhan, China, in December 2019, as a pneumonia causing pathogen. Epidemiological data in Romania show more than 450.000 confirmed patients, with a constant number of approximately 10% admission in intensive care unit.
A retrospective, observational study was conducted from 1st March to 30th October 2020, comprising 657 patients, confirmed as having COVID-19, and who had been admitted to the intensive care unit of the Mures County Clinical Hospital, Tîrgu Mures, Romania, which had been designated as a support hospital during the pandemic. Patients who presented at admission or developed abnormal liver function tests in the first seven days of admission, were included in the study; patients with pre-existing liver disease, were excluded.
The mean (SD) age of patients included in the study was 59.41 (14.66) years with a male: female ratio of 1.51:1. Survivor status, defined as patients discharged from the intensive care unit, was significantly associated with parameters such as age, leukocyte count, albumin level, glycaemia level (p<0.05 for all parameters.).
Liver injury expressed through liver function tests cannot solely constitute a prognostic factor for COVID-19 patients, but its presence in critically ill patients should be further investigated and included in future guideline protocols.
世界卫生组织（WHO）于2019年12月确定起源于中国武汉的一种新型冠状病毒是一种导致肺炎的病原体。罗马尼亚的流行病学数据显示，确诊患者超过45万，重症监护病房的收治人数持续保持在约10%。
于2020年3月1日至10月30日进行了一项回顾性观察研究，纳入657例确诊感染新冠病毒且已入住罗马尼亚特尔古穆列什市穆列什县临床医院重症监护病房的患者，该医院在疫情期间被指定为支援医院。入院时出现或入院后前七天内肝功能检查异常的患者被纳入研究；排除既往有肝病的患者。
纳入研究的患者平均（标准差）年龄为59.41（14.66）岁，男女比例为1.51:1。存活状态定义为从重症监护病房出院的患者，与年龄、白细胞计数、白蛋白水平、血糖水平等参数显著相关（所有参数p<0.05）。
通过肝功能检查表现出的肝损伤不能单独构成新冠病毒感染患者的预后因素，但在重症患者中其存在情况应进一步研究并纳入未来的指南方案。
