Cardinal Sébastien, Ben Lagha Amel, Azelmat Jabrane, Grenier Daniel
Département de biologie, chimie et géographie, Université du Québec à Rimouski, 300 allée des Ursulines, Rimouski, QC, Canada G5L 3A1.
Groupe de recherche en écologie buccale, Faculté de médecine dentaire, Université Laval, 2420 rue de la Terrasse, Québec, QC, Canada G1V 0A6.
ACS Omega. 2021 Oct 13;6(42):27791-27797. doi: 10.1021/acsomega.1c03312. eCollection 2021 Oct 26.
Quebecol is a polyphenolic compound initially isolated from Canadian maple syrup in 2011. Recently, our group demonstrated in a macrophage model that quebecol inhibits the secretion of pro-inflammatory cytokines and reduces the activation of the NF-κB transcription factor. In this study, we further explored the therapeutic potential of quebecol against periodontal disease, an inflammatory disorder of bacterial origin affecting tooth-supporting tissues. More specifically, the effects of this natural compound on matrix metalloproteinase (MMP) activity and macrophage secretion, as well as on the mineralization activity of osteoblasts (bone-forming cells), were investigated. Results showed that exposing lipopolysaccharide (LPS)-treated macrophages to quebecol led to a significant decrease in the secretion of MMP-8 and MMP-9. In addition, quebecol dose dependently inhibited the catalytic activity of MMP-9. Quebecol also enhanced the mineralization activity of osteoblasts. This study brought forward additional evidence to support the potential of quebecol as a nutraceutical agent against periodontitis.
魁北克素是一种多酚类化合物，于2011年首次从加拿大枫糖浆中分离出来。最近，我们小组在巨噬细胞模型中证明，魁北克素可抑制促炎细胞因子的分泌，并降低NF-κB转录因子的激活。在本研究中，我们进一步探索了魁北克素对牙周病的治疗潜力，牙周病是一种影响牙齿支持组织的细菌性炎症疾病。更具体地说，研究了这种天然化合物对基质金属蛋白酶（MMP）活性和巨噬细胞分泌的影响，以及对成骨细胞（骨形成细胞）矿化活性的影响。结果表明，将脂多糖（LPS）处理的巨噬细胞暴露于魁北克素中会导致MMP-8和MMP-9的分泌显著减少。此外，魁北克素剂量依赖性地抑制MMP-9的催化活性。魁北克素还增强了成骨细胞的矿化活性。这项研究提供了更多证据，支持魁北克素作为一种营养保健品对抗牙周炎的潜力。
