Affiliated Foshan Maternity and Child Healthcare Hospital, Southern Medical University (Foshan Maternity & Child Healthcare Hospital), Foshan 528000, China.
Center for Cell Lineage and Atlas (CCLA), Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou 510005, China.
Nucleic Acids Res. 2022 Jan 7;50(D1):D928-D933. doi: 10.1093/nar/gkab1029.
As a means to aid in the investigation of viral infection mechanisms and identification of more effective antivirus targets, the availability of a source which continually collects and updates information on the virus and host ncRNA-associated interaction resources is essential. Here, we update the ViRBase database to version 3.0 (http://www.virbase.org/ or http://www.rna-society.org/virbase/). This update represents a major revision: (i) the total number of interaction entries is now greater than 820,000, an approximately 70-fold increment, involving 116 virus and 36 host organisms, (ii) it supplements and provides more details on RNA annotations (including RNA editing, RNA localization and RNA modification), ncRNA SNP and ncRNA-drug related information and (iii) it provides two additional tools for predicting binding sites (IntaRNA and PRIdictor), a visual plug-in to display interactions and a website which is optimized for more practical and user-friendly operation. Overall, ViRBase v3.0 provides a more comprehensive resource for virus and host ncRNA-associated interactions enabling researchers a more effective means for investigation of viral infections.
为了帮助研究病毒感染机制和鉴定更有效的抗病毒靶标，持续收集和更新有关病毒和宿主 ncRNA 相互作用资源的信息的资源是必不可少的。在这里，我们将 ViRBase 数据库更新到 3.0 版（http://www.virbase.org/ 或 http://www.rna-society.org/virbase/）。此更新代表了一个重大修订：（i）交互条目总数现在大于 820,000，增加了约 70 倍，涉及 116 种病毒和 36 种宿主生物；（ii）它补充并提供了更多关于 RNA 注释（包括 RNA 编辑、RNA 定位和 RNA 修饰）、ncRNA SNP 和 ncRNA 药物相关信息的详细信息；（iii）它提供了两个用于预测结合位点的附加工具（IntaRNA 和 PRIdictor）、一个用于显示相互作用的可视化插件以及一个针对更实用和用户友好的操作进行了优化的网站。总的来说，ViRBase v3.0 为病毒和宿主 ncRNA 相互作用提供了更全面的资源，使研究人员能够更有效地研究病毒感染。
