Li Xin, Zheng Chunfu, Yang Zhen, Liu Gongguan
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu, China.
Department of Microbiology, Immunology & Infectious Diseases, University of Calgary, Calgary, AB, Canada.
Methods Mol Biol. 2025;2940:79-91. doi: 10.1007/978-1-0716-4615-1_8.
Various high-throughput genetic functional screening and physical protein interaction screening methods have been employed to gain a global understanding of how viruses interact with host cells for replication. In this chapter, we provide an overview of the bioinformatics analysis and computational methods of virus-host interactions and highlight their advantages and disadvantages to provide a technical reference for interactive research on virus-host interactomes and the identification of antiviral factors.
为全面了解病毒如何与宿主细胞相互作用以进行复制，人们采用了各种高通量基因功能筛选和物理蛋白质相互作用筛选方法。在本章中，我们概述了病毒 - 宿主相互作用的生物信息学分析和计算方法，并着重介绍了它们的优缺点，以为病毒 - 宿主相互作用组的交互研究和抗病毒因子的鉴定提供技术参考。
