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RNA 定位 v2.0：一个更新的 RNA 亚细胞定位资源，具有更高的覆盖率和注释。

RNALocate v2.0: an updated resource for RNA subcellular localization with increased coverage and annotation.

机构信息

Department of Bioinformatics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

出版信息

Nucleic Acids Res. 2022 Jan 7;50(D1):D333-D339. doi: 10.1093/nar/gkab825.

DOI:10.1093/nar/gkab825
PMID:34551440
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8728251/
Abstract

Resolving the spatial distribution of the transcriptome at a subcellular level can increase our understanding of biology and diseases. To facilitate studies of biological functions and molecular mechanisms in the transcriptome, we updated RNALocate, a resource for RNA subcellular localization analysis that is freely accessible at http://www.rnalocate.org/ or http://www.rna-society.org/rnalocate/. Compared to RNALocate v1.0, the new features in version 2.0 include (i) expansion of the data sources and the coverage of species; (ii) incorporation and integration of RNA-seq datasets containing information about subcellular localization; (iii) addition and reorganization of RNA information (RNA subcellular localization conditions and descriptive figures for method, RNA homology information, RNA interaction and ncRNA disease information) and (iv) three additional prediction tools: DM3Loc, iLoc-lncRNA and iLoc-mRNA. Overall, RNALocate v2.0 provides a comprehensive RNA subcellular localization resource for researchers to deconvolute the highly complex architecture of the cell.

摘要

解析转录组在亚细胞水平上的空间分布可以增进我们对生物学和疾病的理解。为了促进对转录组中生物功能和分子机制的研究，我们更新了 RNA 亚细胞定位分析资源 RNALocate，该资源可在以下网址免费获取：http://www.rnalocate.org/ 或 http://www.rna-society.org/rnalocate/。与 RNALocate v1.0 相比，v2.0 版的新功能包括：(i) 扩充了数据源和物种覆盖范围；(ii) 整合了包含亚细胞定位信息的 RNA-seq 数据集；(iii) 增加和重组了 RNA 信息（RNA 亚细胞定位条件和方法的描述性图片、RNA 同源信息、RNA 相互作用和 ncRNA 疾病信息）；以及 (iv) 三个额外的预测工具：DM3Loc、iLoc-lncRNA 和 iLoc-mRNA。总的来说，RNALocate v2.0 为研究人员提供了一个全面的 RNA 亚细胞定位资源，以解析细胞高度复杂的结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a53/8728251/1a43b6d0d5b7/gkab825fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a53/8728251/6b410d07969f/gkab825fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a53/8728251/a255dab6ab48/gkab825fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a53/8728251/1a43b6d0d5b7/gkab825fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a53/8728251/6b410d07969f/gkab825fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a53/8728251/a255dab6ab48/gkab825fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a53/8728251/1a43b6d0d5b7/gkab825fig3.jpg

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3
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4
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