Laboratory of the Nanostructures Research, Institute of Silicate Chemistry, Russian Academy of Sciences, Adm. Makarova Emb., 2, St. Petersburg 199034, Russia.
Department of General Pathology and Pathological Physiology, Institute of Experimental Medicine, Academic Pavlov Str., 12, St. Petersburg 197376, Russia.
Inorg Chem. 2021 Nov 15;60(22):17008-17018. doi: 10.1021/acs.inorgchem.1c02122. Epub 2021 Nov 1.
A simple one-step method is presented for fabricating inorganic nanosponges with a kaolinite [AlSiO(OH)] structure. The nanosponges were synthesized by the hydrothermal treatment of aluminosilicate gels in an acidic medium (pH = 2.6) at 220 °C without using organic cross-linking agents, such as cyclodextrin or polymers. The formation of the nanosponge morphology was confirmed by scanning electron microscopy, and the assignment of the synthesized aluminosilicates to the kaolinite group was confirmed by X-ray diffraction and infrared spectroscopy. The effect of the synthesis conditions, in particular, the nature (HCl, HF, NaOH, and HO) and pH of the reaction medium (2.6, 7, and 12), as well as the duration of the synthesis (3, 6, and 12 days), on the morphology of aluminosilicates of the kaolinite group was studied. The sorption capacity of aluminosilicate nanosponges with respect to cationic (e.g., methylene blue) and anionic (e.g., azorubine) dyes in aqueous solutions was studied. The pH sensitivity of the surface ζ potential of the synthesized nanosponges was demonstrated. The dependence of the hemolytic activity (the ability to destroy erythrocytes) of aluminosilicate nanoparticles on the particle morphology (platy, spherical, and nanosponge) has been identified for the first time. Aluminosilicate nanosponges were not found to exhibit hemolytic activity. The prospects of using aluminosilicate nanosponges to prepare innovative functional materials for ecology and medicine applications, in particular, as matrices for drug delivery systems, were identified.
一种简单的一步法被提出用于制造具有高岭石[AlSiO(OH)]结构的无机纳米海绵。纳米海绵通过在 220°C 的酸性介质（pH = 2.6）中对铝硅酸盐凝胶进行水热处理而合成，而无需使用有机交联剂，例如环糊精或聚合物。通过扫描电子显微镜证实了纳米海绵形态的形成，并且通过 X 射线衍射和红外光谱证实了合成的铝硅酸盐被分配到高岭石组。研究了合成条件，特别是反应介质的性质（HCl、HF、NaOH 和 H2O）和 pH（2.6、7 和 12）以及合成时间（3、6 和 12 天）对高岭石组铝硅酸盐形态的影响。研究了高岭石组铝硅酸盐纳米海绵对阳离子（例如亚甲蓝）和阴离子（例如偶氮胭脂红）染料在水溶液中的吸附能力。证明了合成纳米海绵表面 ζ 电位的 pH 敏感性。首次确定了合成纳米海绵的溶血活性（破坏红细胞的能力）与颗粒形态（片状、球形和纳米海绵）之间的依赖性。未发现铝硅酸盐纳米海绵具有溶血活性。确定了将铝硅酸盐纳米海绵用于制备生态和医学应用的创新功能材料，特别是作为药物传递系统的基质的前景。
