Golubeva Olga Yu, Alikina Yulia A, Brazovskaya Elena Yu
Laboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova emb., 2, 199034 St. Petersburg, Russia.
Nanomaterials (Basel). 2022 Jul 26;12(15):2559. doi: 10.3390/nano12152559.
A comparative study of the properties of aluminosilicates of the kaolinite (AlSiO(OH)∙nHO) group with different particles morphology has been carried out. Under conditions of directed hydrothermal synthesis, kaolinite nanoparticles with spherical, sponge, and platy morphologies were obtained. Raw nanotubular halloysite was used as particles with tubular morphology. The samples were studied by X-ray diffraction, SEM, solid-state NMR, low-temperature nitrogen adsorption, and the dependence of the zeta potential of the samples on the pH of the medium was defined. The sorption capacity with respect to cationic dye methylene blue in aqueous solutions was studied. It was found that sorption capacity depends on particles morphology and decreases in the series spheres-sponges-tubes-plates. The Langmuir, Freundlich, and Temkin models describe experimental methylene blue adsorption isotherms on aluminosilicates of the kaolinite subgroup with different particles morphology. To process the kinetic data, pseudo-first order and pseudo-second order were used. For the first time, studies of the dependence of hemolytic activity and cytotoxicity of aluminosilicate nanoparticles on their morphology were carried out. It was found that aluminosilicate nanosponges and spherical particles are not toxic to human erythrocytes and do not cause their destruction at sample concentrations from 0.1 to 1 mg/g. Based on the results of the MTT test, the concentration value that causes 50% inhibition of cell population growth (IC, mg/mL) was calculated. For nanotubes, this value turned out to be the smallest-0.33 mg/mL. For samples with platy, spherical and nanosponge morphology, the IC values were 1.55, 2.68, and 4.69 mg/mL, respectively.
对不同颗粒形态的高岭石（AlSiO(OH)∙nH₂O）族铝硅酸盐的性质进行了比较研究。在定向水热合成条件下，获得了具有球形、海绵状和片状形态的高岭石纳米颗粒。将原始的管状埃洛石用作具有管状形态的颗粒。通过X射线衍射、扫描电子显微镜、固态核磁共振、低温氮吸附对样品进行了研究，并确定了样品的ζ电位对介质pH值的依赖性。研究了在水溶液中对阳离子染料亚甲基蓝的吸附容量。发现吸附容量取决于颗粒形态，并且在球形-海绵状-管状-片状的序列中降低。Langmuir、Freundlich和Temkin模型描述了不同颗粒形态的高岭石亚组铝硅酸盐上亚甲基蓝的实验吸附等温线。为了处理动力学数据，使用了伪一级和伪二级模型。首次对铝硅酸盐纳米颗粒的溶血活性和细胞毒性对其形态的依赖性进行了研究。发现铝硅酸盐纳米海绵和球形颗粒对人体红细胞无毒，并且在样品浓度为0.1至1 mg/g时不会导致其破坏。基于MTT试验的结果，计算了导致细胞群体生长50%抑制的浓度值（IC₅₀，mg/mL）。对于纳米管，该值最小，为0.33 mg/mL。对于具有片状、球形和纳米海绵形态的样品，IC₅₀值分别为1.55、2.68和4.69 mg/mL。
