IS 家族元件在猪源大肠杆菌分离株中（X4）的动员。
Mobilization of (X4) by IS Family Elements in Porcine Escherichia coli Isolates.
机构信息
College of Veterinary Medicine, Henan Agricultural Universitygrid.108266.b, Zhengzhou, P. R. China.
Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.
出版信息
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0159721. doi: 10.1128/AAC.01597-21. Epub 2021 Nov 1.
Abstract
The dissemination mechanism of the high-level tigecycline resistance gene (X4) in porcine Escherichia coli was investigated. (X4) and other antimicrobial resistance genes were located on the plasmids p1919D3-1 and p1919D62-1 and flanked by two or three copies of IS family elements, which can form one to three translocatable units (TUs). Using a reduced transposition model, IS was experimentally demonstrated to mediate the transposition of (X4) from a suicide plasmid into the E. coli chromosome.
摘要
研究了高水平替加环素耐药基因（X4）在猪大肠杆菌中的传播机制。（X4）和其他抗菌药物耐药基因位于质粒 p1919D3-1 和 p1919D62-1 上，两侧是两到三个 IS 家族元件，这些元件可以形成一个到三个可转位单元（TU）。通过一个简化的转座模型，实验证明 IS 介导了（X4）从自杀质粒转移到大肠杆菌染色体上。
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