plastic surgeon in private practice in San Diego, CA, USA.
University of California, Los Angeles, Los Angeles, CA, USA.
Aesthet Surg J. 2022 Mar 15;42(4):327-339. doi: 10.1093/asj/sjab379.
A standardized technique for facial fat grafting, injectable tissue replacement and regeneration (ITR2), incorporating new regenerative approaches, was developed to address anatomic volume losses in superficial and deep fat compartments as well as skin aging.
The aim of this study was to track the short- and long-term effects of facial fat grafting by ITR2 in the midfacial zone over 19 months.
Twenty-nine females were analyzed for midfacial volume changes after autologous fat transfer with ITR2 with varying fat parcel sizes. Volumes were evaluated with an imaging system to calculate differences between a predefined, 3-dimensional midfacial zone measured preoperatively and after fat grafting.
Patient data were analyzed collectively and by age (<55 and >55 years). Collective analysis revealed a trend of initial volume loss during Months 1 to 7 followed by an increase during Months 8 to 19, averaging 56.6% postoperative gain, and ending at an average of 52.3% gain in volume by 14 to 19 months. A similar trend was observed for patients <55 years of age, with a 54.1% average postoperative gain and a greater final average of 75.2%. Conversely, patients >55 years of age revealed a linear decay from 60.6% to 29.5%. Multiple regression analysis revealed no statistically significant influence of weight change throughout the study.
A dynamic change in facial volume was observed, with an initial decrease in facial volume followed by a rebound effect, by 19 months after treatment, of improved facial volume regardless of the amount of fat injected. Volume improvement was greater in patients <55 years old, whereas in patients >55 years old, volume gradually decreased. This study represents the first time that progressive improvement in facial volume has been shown 19 months after treatment.
为了解决面部浅表和深部脂肪间隙以及皮肤老化导致的解剖体积丢失问题，我们开发了一种标准化的面部脂肪移植、注射式组织置换和再生（ITR2）技术，该技术融合了新的再生方法。
本研究旨在通过 ITR2 在 19 个月的时间内跟踪中面部区域面部脂肪移植的短期和长期效果。
对 29 名女性进行了自体脂肪移植后中面部体积变化的分析，所用方法为 ITR2 联合不同大小的脂肪包裹。使用成像系统评估体积，以计算术前和脂肪移植后预设的三维中面部区域之间的差异。
对所有患者数据进行了综合分析和年龄（<55 岁和>55 岁）分组分析。综合分析显示，在第 1 至 7 个月期间存在初始体积损失的趋势，随后在第 8 至 19 个月期间增加，平均术后获得 56.6%的体积增加，并在 14 至 19 个月时平均获得 52.3%的体积增加。<55 岁患者也观察到了类似的趋势，平均术后获得 54.1%的体积增加，最终平均体积增加 75.2%。相反，>55 岁的患者则呈现出从 60.6%到 29.5%的线性下降。多元回归分析显示，在整个研究过程中，体重变化没有统计学意义。
无论注射脂肪量多少，治疗后 19 个月都观察到面部体积的动态变化，最初的面部体积减少，随后出现反弹效应，从而改善面部体积。<55 岁的患者体积改善更大，而>55 岁的患者则逐渐减少。本研究首次表明，治疗后 19 个月面部体积会持续改善。
