Lioli Eutuxia, Kollia Eleni, Markaki Panagiota, Mitsopoulou Christiana A
Laboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens , Panepistimiopolis Zografou, 15771 Athens, Greece.
Laboratory of Food Chemistry, Department of Chemistry, National and Kapodistrian University of Athens , Panepistimiopolis Zografou, 15784 Athens, Greece.
FEMS Microbiol Lett. 2021 Nov 12;368(19). doi: 10.1093/femsle/fnab136.
The issue of food contamination by fungi and aflatoxins; constitutes a serious concern not only for human/animal health but also for agriculture and the economy. Aflatoxins are secondary metabolites produced by certain filamentous fungi and contaminate a variety of foodstuffs. In this context, control of fungal growth and aflatoxin contamination appears to be important. The present study aimed to investigate new Cu(I) and Cu(II)-quinoxaline complexes, namely Cu(2,2´-pq)(NO3) (1), Cu(2,2´-pq)2(NO3)·6H2O (2) and Cu(2,2΄-pq)2 (3), where 2,2´-pq is 2-(2'-pyridyl quinoxaline), as antifungal agents against Aspergillus parasiticus. All complexes, the ligand and the starting material Cu(NO3)2-3H2O, regardless of the concentration used, caused inhibition of A. parasiticus growth ranged from 8.52 to 33.33%. The fungal growth inhibition was triggered when irradiation in visible (λ > 400 nm) was continuously applied (range 18.36-57.20%). The highest inhibitory activity was exhibited by the complex Cu(2,2´-pq)2(NO3)·6H2O and for this reason, it was selected to be studied for its ability to suppress aflatoxin B1 produced by A. parasiticus. AFB1 production after the irradiation process was found to be suppressed by 25% compared to AFB1 produced in dark conditions.
真菌和黄曲霉毒素对食品的污染问题；不仅对人类/动物健康，而且对农业和经济都构成严重关切。黄曲霉毒素是某些丝状真菌产生的次生代谢产物，会污染各种食品。在这种情况下，控制真菌生长和黄曲霉毒素污染似乎很重要。本研究旨在研究新型的Cu(I)和Cu(II)-喹喔啉配合物，即Cu(2,2´-pq)(NO3) (1)、Cu(2,2´-pq)2(NO3)·6H2O (2) 和 Cu(2,2΄-pq)2 (3)，其中2,2´-pq为2-(2'-吡啶基喹喔啉)，作为抗寄生曲霉的抗真菌剂。所有配合物、配体和起始原料Cu(NO3)2·3H2O，无论使用的浓度如何，对寄生曲霉生长的抑制率在8.52%至33.
