高强度间歇训练与中等强度持续训练对肝脏脂肪的影响：系统评价和荟萃分析。

The Effect of High-intensity Interval Training vs Moderate-intensity Continuous Training on Liver Fat: A Systematic Review and Meta-Analysis.

机构信息

NICM Health Research Institute, Western Sydney University, Westmead, New South Wales 2145, Australia.

School of Health Sciences, Western Sydney University, Campbelltown, New South Wales 2560, Australia.

出版信息

J Clin Endocrinol Metab. 2022 Feb 17;107(3):862-881. doi: 10.1210/clinem/dgab795.

DOI:10.1210/clinem/dgab795

PMID:34724062

Abstract

CONTEXT

Non-alcoholic fatty liver disease, characterized by excess fat accumulation in the liver, is considered the hepatic manifestation of metabolic syndrome. Recent findings have shown that high-intensity interval training (HIIT) can reduce liver fat but it is unclear whether this form of exercise is superior to traditional moderate-intensity continuous training (MICT).

OBJECTIVE

The aim of this systematic review was to determine the effect of HIIT vs MICT on liver fat in adults. A secondary aim was to investigate the interaction between total weekly exercise volume and exercise-related energy expenditure and change in liver fat.

METHODS

Relevant databases were searched up to December 2020 for randomized trials, comparing HIIT to control, MICT to control, or HIIT to MICT. Studies were excluded if they did not implement 2 or more weeks' intervention or assess liver fat using magnetic resonance-based techniques. Weighted mean differences and 95% CIs were calculated. Regression analyses were undertaken to determine the interaction between weekly exercise volume in minutes and kilocalories (kcal) with change in liver fat content.

RESULTS

Of the 28 268 studies screened, 19 were included involving 745 participants. HIIT and MICT both elicited moderate reductions in liver fat content when compared to control (HIIT: -2.85%, 95% CI, -4.86 to -0.84, P = .005, I2 = 0%, n = 114, low-certainty evidence; MICT: -3.14%, 95% CI, -4.45 to -1.82, P < .001, I2 = 5.2%, n = 533, moderate-certainty evidence). There was no difference between HIIT and MICT (-0.34%, 95% CI, -2.20 to 1.52, P = .721, I2 = 0%, n = 177, moderate-certainty evidence). Neither total exercise volume in minutes (β = .0002, SE = 0.0017, Z = 0.13, P = .89) nor exercise-related energy expenditure in kcal (β = .0003, SE = 0.0002, Z = 1.21, P = .23) were related to changes in liver fat content.

CONCLUSION

HIIT elicits comparable improvements in liver fat to MICT despite often requiring less energy and time commitment. Further studies should be undertaken to assess the relative importance of aerobic exercise prescription variables, such as intensity, on liver fat.

摘要

背景

非酒精性脂肪性肝病的特征是肝脏中脂肪堆积过多，被认为是代谢综合征的肝脏表现。最近的研究结果表明，高强度间歇训练（HIIT）可以减少肝脏脂肪，但尚不清楚这种运动形式是否优于传统的中等强度持续训练（MICT）。

目的

本系统评价的目的是确定 HIIT 与 MICT 对成年人肝脏脂肪的影响。次要目的是研究总每周运动量与与运动相关的能量消耗之间的相互作用与肝脏脂肪变化。

方法

检索截至 2020 年 12 月的相关数据库，比较 HIIT 与对照、MICT 与对照或 HIIT 与 MICT 的随机试验。如果试验未实施 2 周或更长时间的干预或使用基于磁共振的技术评估肝脏脂肪，则将其排除在外。计算了加权均数差和 95%置信区间。进行回归分析以确定每周运动量（分钟）和卡路里（kcal）与肝脏脂肪含量变化之间的相互作用。

结果

在筛选的 28268 项研究中，有 19 项研究纳入了 745 名参与者。与对照组相比，HIIT 和 MICT 均能适度降低肝脏脂肪含量（HIIT：-2.85%，95%CI，-4.86 至-0.84，P=0.005，I2=0%，n=114，低确定性证据；MICT：-3.14%，95%CI，-4.45 至-1.82，P<0.001，I2=5.2%，n=533，中等确定性证据）。HIIT 与 MICT 之间无差异（-0.34%，95%CI，-2.20 至 1.52，P=0.721，I2=0%，n=177，中等确定性证据）。分钟的总运动量（β=0.0002，SE=0.0017，Z=0.13，P=0.89）和卡路里的运动相关能量消耗（β=0.0003，SE=0.0002，Z=1.21，P=0.23）均与肝脏脂肪含量变化无关。