Department of Obstetrics, Daqing People's Hospital, Daqing, Heilongjiang, China.
Department of Obstetrics, Daqing, Heilongjiang, China.
Women Health. 2021 Nov-Dec;61(10):957-967. doi: 10.1080/03630242.2021.1994512. Epub 2021 Nov 1.
Preeclampsia (PE) is one of the major contributors to maternal and fetal mortality worldwide. Many host-related biomolecules regulate the pathophysiology of PE. The current study aims to examine the role of the renalase in PE manifestations. A total of 384 Chinese women consisting of subjects with normotensive pregnancy (n = 105), women with PE (n = 121), and healthy women (n = 158) were included in the study. Serum renalase level was measured in all subjects by ELISA. Renalase gene polymorphisms (rs10887800, rs2576178, and rs2296545) were genotyped by PCR-RFLP. The pregnant women had elevated renalase levels compared to healthy controls and subjects with PE. Renalase level was negatively correlated with systolic and diastolic blood pressure. Interestingly, renalase was positively correlated with the glomerular filtration rate. Prevalence of homozygous mutant (GG) and minor allele (G) for rs10887800 and rs2576178 renalase gene polymorphisms were significantly higher in PE patients compared to normotensive pregnant women and healthy controls. Furthermore, an association of G-G-C haplotype with susceptibility to PE was also noticed. A low level of renalase may be associated with an increased risk of PE during pregnancy. Renalase gene polymorphisms (rs10887800 and rs2576178) are correlated with serum renalase and are associated with predisposition to PE development in the Chinese cohort.
子痫前期 (PE) 是全球孕产妇和胎儿死亡的主要原因之一。许多与宿主相关的生物分子调节 PE 的病理生理学。本研究旨在研究肾酶在 PE 表现中的作用。共有 384 名中国妇女，包括正常妊娠受试者（n=105）、PE 妇女（n=121）和健康妇女（n=158）纳入研究。所有受试者的血清肾酶水平均通过 ELISA 进行测量。通过 PCR-RFLP 对肾酶基因多态性（rs10887800、rs2576178 和 rs2296545）进行基因分型。与健康对照组和 PE 组相比，孕妇的肾酶水平升高。肾酶水平与收缩压和舒张压呈负相关。有趣的是，肾酶与肾小球滤过率呈正相关。与正常妊娠妇女和健康对照组相比，PE 患者 rs10887800 和 rs2576178 肾酶基因多态性的纯合突变 (GG) 和次要等位基因 (G) 的发生率显著更高。此外，还注意到 G-G-C 单倍型与 PE 的易感性有关。肾酶水平低可能与妊娠期间发生 PE 的风险增加有关。肾酶基因多态性（rs10887800 和 rs2576178）与血清肾酶相关，与中国队列中 PE 发病的易感性相关。
