Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cellular & Molecular Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.
Per Med. 2024;21(3):191-204. doi: 10.1080/17410541.2024.2341608. Epub 2024 May 28.
The authors designed a meta-analysis to find a comprehensive result of the impact of polymorphisms on preeclampsia (PE) susceptibility. The online databases PubMed, Scopus, and Google Scholar were employed for the purpose of literature search. Data analysis was conducted using STATA (ver. 12.0) and MetaGenyo web tool. The findings showed that the rs10887800 polymorphism could increase risk of PE in allelic, codominant heterozygous and dominant genetic models. In addition, the analysis indicated that the rs2576178 polymorphism was associated with higher risk of PE in allelic, codominant homozygous, dominant, and recessive models. The findings of meta-analysis showed that the rs10887800 and rs2576178 polymorphisms could increase risk of PE in several genetic models.
作者设计了一项荟萃分析，以找到关于多态性对先兆子痫（PE）易感性影响的综合结果。为此目的，使用了在线数据库 PubMed、Scopus 和 Google Scholar 进行文献搜索。使用 STATA（版本 12.0）和 MetaGenyo 网络工具进行数据分析。研究结果表明，rs10887800 多态性在等位基因、杂合子和显性遗传模型中可增加 PE 的风险。此外，分析表明 rs2576178 多态性在等位基因、纯合子、显性和隐性模型中与更高的 PE 风险相关。荟萃分析的结果表明，rs10887800 和 rs2576178 多态性在几种遗传模型中可增加 PE 的风险。
